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A New Danshensu Derivative Protects Against 6-Hydroxydopamine-Induced Neurotoxicity in Vitro and in Vivo
Guozhen Cui1,2; Luchen Shan3; Yang Chen2; Hefeng Zhou1; Yuqiang Wang3; Simon Ming-Yuen Lee1
2016-10-01
Source PublicationAmerican Journal of Chinese Medicine
ISSN0192415X
Volume44Issue:7Pages:1349-1361
Abstract

We previously reported a novel danshensu derivative (R)-(3,5,6-Trimethylpyrazinyl) methyl-2-acetoxy-3-(3,4-diacetoxyphenyl) propanoate (ADTM), which conferred cardioprotective and anti-thrombotic effects in vitro and in vivo. Here, we examined the neuroprotective actions of ADTM on 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in PC12 cells 1 in vitro and zebrafish in vivo. Pretreatment with ADTM significantly inhibited 6-OHDA-induced cytotoxicity and production of reactive oxygen species (ROS) in PC12 cells through Akt signaling. Moreover, treatment with ADTM also inhibited expression of inducible nitric oxide synthase (iNOS) and production of intracellular nitric oxide (NO), which are associated with inflammation. In addition, ADTM exhibited significant protection against 6-OHDA-induced loss of tyrosine hydroxylase-positive dopaminergic neurons in a zebrafish model. Taken together, our findings suggest that ADTM is also a potential effective therapeutic agent for neurodegenerative conditions such as Parkinson's disease (PD) through anti-oxidant cytoprotective and anti-inflammatory actions.

KeywordAnti-inflammation Anti-oxidation Danshensu Derivative Neuroprotection
DOI10.1142/S0192415X16500750
URLView the original
Language英语
WOS Research AreaIntegrative & Complementary Medicine ; General & Internal Medicine
WOS SubjectIntegrative & Complementary Medicine ; Medicine, General & Internal
WOS IDWOS:000387901300003
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorSimon Ming-Yuen Lee
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macao, P.R. China
2.Zhuhai Key Laboratory of Basic and Applied Research in Chinese Medicine, Department of Bioengineering, Zhuhai Campus of Zunyi Medical College, Zhuhai, P.R. China
3.Institute of New Drug Research, College of Pharmacy, Jinan University, Guangzhou, P.R. China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Guozhen Cui,Luchen Shan,Yang Chen,et al. A New Danshensu Derivative Protects Against 6-Hydroxydopamine-Induced Neurotoxicity in Vitro and in Vivo[J]. American Journal of Chinese Medicine,2016,44(7):1349-1361.
APA Guozhen Cui,Luchen Shan,Yang Chen,Hefeng Zhou,Yuqiang Wang,&Simon Ming-Yuen Lee.(2016).A New Danshensu Derivative Protects Against 6-Hydroxydopamine-Induced Neurotoxicity in Vitro and in Vivo.American Journal of Chinese Medicine,44(7),1349-1361.
MLA Guozhen Cui,et al."A New Danshensu Derivative Protects Against 6-Hydroxydopamine-Induced Neurotoxicity in Vitro and in Vivo".American Journal of Chinese Medicine 44.7(2016):1349-1361.
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