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Chemical and pharmacological evaluations on the extract of Scutellaria baicalensis Georgi (Huang-Qin) prepared by various extraction methods
Zhou X.1; Choi P.S.5; Yang J.-M.1; Or P.M.Y.1; Hoi P.M.5; Lee S.M.Y.5; Leung G.P.H.4; Ngai S.M.1; Kong S.K.1; Ho H.P.1; Wong M.Y.M.3; Chan S.W.3; Yeung J.H.K.1; Kwan Y.W.1
2016-12-01
Source PublicationSpringerPlus
ISSN21931801
Volume5Issue:1
AbstractBackground: This study reported a comprehensive approach (comparing the extraction yields, chemical profiles, antioxidant properties and CYP450-inhibitory effects) to evaluated the effectiveness of various extraction methods [microwave-assisted extraction using water (MAE-W), heat reflux extraction using water (HRE-W), ultrasonic extraction using 70 % ethanol and ultrasonic extraction using ethanol (UE-E)] for Huang-Qin (HQ), the dried root of Scutellaria baicalensis Georgi. Results: The HQ extraction efficiency by MAE-W was the best. The chemical profiles of extracts obtained using HRE-W and MAE-W were similar; whereas more flavones but less flavone glycosides were detected in the UE-E extract. There was no difference in the antioxidant properties among different extracts. In vitro human liver microsome assays illustrated that all extracts possessed herb–drug interaction potentials but the UE-E extract are shown with a potent interaction with CYP3A4-metabolized drugs. Conclusion: MAE-W is a favorable method for the preparation of HQ extracts based on extraction yield, pharmacological properties and safety.
KeywordAntioxidant properties Extraction efficiency Herb–drug interaction Scutellaria baicalensis Georgi
DOI10.1186/s40064-016-3115-3
URLView the original
Language英語
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Chinese University of Hong Kong
2.Technological and Higher Education Institute of Hong Kong
3.Hong Kong Polytechnic University
4.The University of Hong Kong
5.University of Macau
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Zhou X.,Choi P.S.,Yang J.-M.,et al. Chemical and pharmacological evaluations on the extract of Scutellaria baicalensis Georgi (Huang-Qin) prepared by various extraction methods[J]. SpringerPlus,2016,5(1).
APA Zhou X..,Choi P.S..,Yang J.-M..,Or P.M.Y..,Hoi P.M..,...&Kwan Y.W..(2016).Chemical and pharmacological evaluations on the extract of Scutellaria baicalensis Georgi (Huang-Qin) prepared by various extraction methods.SpringerPlus,5(1).
MLA Zhou X.,et al."Chemical and pharmacological evaluations on the extract of Scutellaria baicalensis Georgi (Huang-Qin) prepared by various extraction methods".SpringerPlus 5.1(2016).
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