UM
Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis via Concurrently Inhibiting GSK3β and the ERK Pathway
Yu J.1; Zheng J.1; Lin J.1; Jin L.2; Yu R.1; Mak S.4; Hu S.4; Sun H.1; Wu X.1; Zhang Z.5; Lee M.6; Tsim W.3; Su W.2; Zhou W.1; Cui W.1; Han Y.4; Wang Q.1
2017-05-01
Source PublicationCellular and Molecular Neurobiology
ISSN15736830 02724340
Volume37Issue:4Pages:655-664
AbstractOxidative stress-induced neuronal apoptosis plays an important role in many neurodegenerative disorders. In this study, we have shown that indirubin-3-oxime, a derivative of indirubin originally designed for leukemia therapy, could prevent hydrogen peroxide (HO)-induced apoptosis in both SH-SY5Y cells and primary cerebellar granule neurons. HO exposure led to the increased activities of glycogen synthase kinase 3β (GSK3β) and extracellular signal-regulated kinase (ERK) in SH-SY5Y cells. Indirubin-3-oxime treatment significantly reversed the altered activity of both the PI3-K/Akt/GSK3β cascade and the ERK pathway induced by HO. In addition, both GSK3β and mitogen-activated protein kinase inhibitors significantly prevented HO-induced neuronal apoptosis. Moreover, specific inhibitors of the phosphoinositide 3-kinase (PI3-K) abolished the neuroprotective effects of indirubin-3-oxime against HO-induced neuronal apoptosis. These results strongly suggest that indirubin-3-oxime prevents HO-induced apoptosis via concurrent inhibiting GSK3β and the ERK pathway in SH-SY5Y cells, providing support for the use of indirubin-3-oxime to treat neurodegenerative disorders caused or exacerbated by oxidative stress.
KeywordERK GSK3β H2O2 Indirubin-3-oxime PI3-K
DOI10.1007/s10571-016-0402-z
URLView the original
Language英語
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Cited Times [WOS]:10   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Ningbo University
2.Ningbo Xiaoshi High School
3.Hong Kong University of Science and Technology
4.Hong Kong Polytechnic University
5.Jinan University
6.University of Macau
Recommended Citation
GB/T 7714
Yu J.,Zheng J.,Lin J.,et al. Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis via Concurrently Inhibiting GSK3β and the ERK Pathway[J]. Cellular and Molecular Neurobiology,2017,37(4):655-664.
APA Yu J..,Zheng J..,Lin J..,Jin L..,Yu R..,...&Wang Q..(2017).Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis via Concurrently Inhibiting GSK3β and the ERK Pathway.Cellular and Molecular Neurobiology,37(4),655-664.
MLA Yu J.,et al."Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis via Concurrently Inhibiting GSK3β and the ERK Pathway".Cellular and Molecular Neurobiology 37.4(2017):655-664.
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