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Identification of long non-coding RNAs in two anthozoan species and their possible implications for coral bleaching
Huang C.1; Morlighem J.-E.R.L.2,3; Cai J.1; Liao Q.1; Perez C.D.4; Gomes P.B.5; Guo M.1; Radis-Baptista G.2; Lee S.M.-Y.1
2017-12-01
Source PublicationScientific Reports
ISSN20452322
Volume7Issue:1
Abstract

Long non-coding RNAs (lncRNAs) have been shown to play regulatory roles in a diverse range of biological processes and are associated with the outcomes of various diseases. The majority of studies about lncRNAs focus on model organisms, with lessened investigation in non-model organisms to date. Herein, we have undertaken an investigation on lncRNA in two zoanthids (cnidarian): Protolpalythoa varibilis and Palythoa caribaeorum. A total of 11,206 and 13,240 lncRNAs were detected in P. variabilis and P. caribaeorum transcriptome, respectively. Comparison using NONCODE database indicated that the majority of these lncRNAs is taxonomically species-restricted with no identifiable orthologs. Even so, we found cases in which short regions of P. caribaeorum's lncRNAs were similar to vertebrate species' lncRNAs, and could be associated with lncRNA conserved regulatory functions. Consequently, some high-confidence lncRNA-mRNA interactions were predicted based on such conserved regions, therefore revealing possible involvement of lncRNAs in posttranscriptional processing and regulation in anthozoans. Moreover, investigation of differentially expressed lncRNAs, in healthy colonies and colonial individuals undergoing natural bleaching, indicated that some up-regulated lncRNAs in P. caribaeorum could posttranscriptionally regulate the mRNAs encoding proteins of Ras-mediated signal transduction pathway and components of innate immune-system, which could contribute to the molecular response of coral bleaching.

DOI10.1038/s41598-017-02561-y
URLView the original
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000405388900005
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macau, China
2.Laboratory of Biochemistry and Biotechnology, Institute for Marine Sciences, Federal University of Ceará, Fortaleza, Brazil
3.Northeast Biotechnology Network (RENORBIO), Post-graduation program in Biotechnology, Federal University of Ceará, Fortaleza, Brazil
4.Centro Acadêmico de Vitoria, Universidade Federal de Pernambuco, Vitória de Santo Antão, Brazil
5.Departamento de Biologia, Universidade Federal Rural de Pernambuco, Recife, Brazil
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Huang C.,Morlighem J.-E.R.L.,Cai J.,et al. Identification of long non-coding RNAs in two anthozoan species and their possible implications for coral bleaching[J]. Scientific Reports,2017,7(1).
APA Huang C..,Morlighem J.-E.R.L..,Cai J..,Liao Q..,Perez C.D..,...&Lee S.M.-Y..(2017).Identification of long non-coding RNAs in two anthozoan species and their possible implications for coral bleaching.Scientific Reports,7(1).
MLA Huang C.,et al."Identification of long non-coding RNAs in two anthozoan species and their possible implications for coral bleaching".Scientific Reports 7.1(2017).
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