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The holo-transcriptome of the zoantharian protopalythoa variabilis (cnidaria: Anthozoa): A plentiful source of enzymes for potential application in green chemistry, industrial and pharmaceutical biotechnology
Morlighem J.-E.R.L.1; Huang C.5; Liao Q.5; Gomes P.B.4; Perez C.D.3; Prieto-da-Silva A.R.D.B.2; Lee S.M.-Y.5; Radis-Baptista G.1
2018-06-01
Source PublicationMarine Drugs
ISSN16603397
Volume16Issue:6
AbstractMarine invertebrates, such as sponges, tunicates and cnidarians (zoantharians and scleractinian corals), form functional assemblages, known as holobionts, with numerous microbes. This type of species-specific symbiotic association can be a repository of myriad valuable low molecular weight organic compounds, bioactive peptides and enzymes. The zoantharian Protopalythoa variabilis (Cnidaria: Anthozoa) is one such example of a marine holobiont that inhabits the coastal reefs of the tropical Atlantic coast and is an interesting source of secondary metabolites and biologically active polypeptides. In the present study, we analyzed the entire holo-transcriptome of P. variabilis, looking for enzyme precursors expressed in the zoantharian-microbiota assemblage that are potentially useful as industrial biocatalysts and biopharmaceuticals. In addition to hundreds of predicted enzymes that fit into the classes of hydrolases, oxidoreductases and transferases that were found, novel enzyme precursors with multiple activities in single structures and enzymes with incomplete Enzyme Commission numbers were revealed. Our results indicated the predictive expression of thirteen multifunctional enzymes and 694 enzyme sequences with partially characterized activities, distributed in 23 sub-subclasses. These predicted enzyme structures and activities can prospectively be harnessed for applications in diverse areas of industrial and pharmaceutical biotechnology.
KeywordCnidarian transcriptome Holo-transcriptome Marine biocatalyst Marine biotechnology Marine enzyme Pharmaceutical biotechnology Zoanthidea
DOI10.3390/md16060207
URLView the original
Language英語
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Universidade Federal do Ceara
2.Instituto Butantan
3.Universidade de Pernambuco
4.Universidade Federal Rural de Pernambuco
5.University of Macau
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Morlighem J.-E.R.L.,Huang C.,Liao Q.,et al. The holo-transcriptome of the zoantharian protopalythoa variabilis (cnidaria: Anthozoa): A plentiful source of enzymes for potential application in green chemistry, industrial and pharmaceutical biotechnology[J]. Marine Drugs,2018,16(6).
APA Morlighem J.-E.R.L..,Huang C..,Liao Q..,Gomes P.B..,Perez C.D..,...&Radis-Baptista G..(2018).The holo-transcriptome of the zoantharian protopalythoa variabilis (cnidaria: Anthozoa): A plentiful source of enzymes for potential application in green chemistry, industrial and pharmaceutical biotechnology.Marine Drugs,16(6).
MLA Morlighem J.-E.R.L.,et al."The holo-transcriptome of the zoantharian protopalythoa variabilis (cnidaria: Anthozoa): A plentiful source of enzymes for potential application in green chemistry, industrial and pharmaceutical biotechnology".Marine Drugs 16.6(2018).
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