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BHDPC is a novel neuroprotectant that provides anti-neuroinflammatory and neuroprotective effects by inactivating NF-κB and activating PKA/CREB
Li C.3; Chen T.3; Zhou H.3; Feng Y.3; Hoi M.P.M.3; Ma D.1; Zhao C.1; Zheng Y.3; Lee S.M.Y.3
2018-06-25
Source PublicationFrontiers in Pharmacology
ISSN16639812
Volume9Issue:JUN
AbstractMicroglia-mediated neuroinflammatory responses are inevitable and important pathological processes in several kinds of disorder of the central nervous system (CNS). Therefore, alleviating activated microglia-induced inflammatory process might be a valuable therapeutic approach to neuroinflammation-related diseases. In the present study, we investigated BHDPC, a novel neuroprotectant discovered in our previous study that had anti-inflammatory effects under neuroinflammatory conditions. First, we found that BHDPC could inhibit neuroinflammatory responses and promote microglial M2 phenotype polarization in both lipopolysaccharide (LPS)-activated BV-2 microglia l cells. Furthermore, BHDPC provided protective actions against neuroinflammation-induced neurotoxicity in HT22 mouse hippocampal cells co-cultured with activated BV-2 microglia. Further experiments demonstrated that BHDPC could suppress LPS-induced activation of transcription factor nuclear factor kappa B (NF-κB) via interfering with the degradation of the inhibitor of kappa B (IκB) and phosphorylation of IκB, the IκB kinase (IKK). Moreover, we also found that BHDPC could induce phosphorylation of cAMP-dependent protein kinase A (PKA) and cAMP-response element-binding protein (CREB) in BV-2 microglial cells. Also, using the PKA-specific inhibitor, we found that BHDPC-induced CREB phosphorylation was dependent on PKA, which also contributed to BHDPC-mediated anti-inflammation and neuroprotection.
KeywordBHDPC CREB Microglia Neuroinflammation NF-κB PKA
DOI10.3389/fphar.2018.00614
URLView the original
Language英語
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute
2.Guangzhou University of Traditional Chinese Medicine
3.University of Macau
First Author AffilicationUniversity of Macau
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GB/T 7714
Li C.,Chen T.,Zhou H.,et al. BHDPC is a novel neuroprotectant that provides anti-neuroinflammatory and neuroprotective effects by inactivating NF-κB and activating PKA/CREB[J]. Frontiers in Pharmacology,2018,9(JUN).
APA Li C..,Chen T..,Zhou H..,Feng Y..,Hoi M.P.M..,...&Lee S.M.Y..(2018).BHDPC is a novel neuroprotectant that provides anti-neuroinflammatory and neuroprotective effects by inactivating NF-κB and activating PKA/CREB.Frontiers in Pharmacology,9(JUN).
MLA Li C.,et al."BHDPC is a novel neuroprotectant that provides anti-neuroinflammatory and neuroprotective effects by inactivating NF-κB and activating PKA/CREB".Frontiers in Pharmacology 9.JUN(2018).
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