UM
Schisantherin a attenuates neuroinflammation in activated microglia: Role of Nrf2 activation through ERK phosphorylation
Li C.3; Chen T.2; Zhou H.3; Zhang C.3; Feng Y.3; Tang F.3; Hoi M.P.-M.3; He C.3; Zheng Y.3; Lee S.M.-Y.3
2018-07-01
Source PublicationCellular Physiology and Biochemistry
ISSN14219778 10158987
Volume47Issue:5Pages:1769-1784
AbstractBackground/Aims: In the present study, we investigated whether schisantherin A (StA) had anti-inflammatory effects under neuroinflammatory conditions. Methods: The effects of StA and its underlying mechanisms were examined in lipopolysaccharide (LPS)-activated BV-2 microglial cells by ELISA, qPCR, EMSA, Western blot, and IHC. Results: Firstly, we found that StA inhibited the inflammatory response in LPS-activated BV-2 microglia. Secondly, we found that StA suppressed LPS-induced activation of NF-κB via interfering with degradation of IκB and phosphorylation of IκB, IKK, PI3K/Akt, JNK, and p38 MAPK. Thirdly, StA conferred indirect antioxidative effects via quenching ROS and promoted expression of antioxidant enzymes, including HO-1 and NQO-1, via stimulating activation of Nrf2 pathways. Finally, we demonstrated that anti-neuroinflammatory actions of StA were dependent on ERK phosphorylation-mediated Nrf2 activation. Conclusion: StA induced ERK phosphorylation-mediated Nrf2 activation, which contributed to its anti-inflammation and anti-oxidation. The anti-neuroinflammatory and anti-oxidative effects of StA may show preventive therapeutic potential for various neuroinflammatory disorders.
KeywordMicroglia Neuroinflammation NF-κB Nrf2 Schisantherin A
DOI10.1159/000491059
URLView the original
Language英語
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Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Beijing University of Chinese Medicine
2.Guangzhou University of Traditional Chinese Medicine
3.University of Macau
First Author AffilicationUniversity of Macau
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GB/T 7714
Li C.,Chen T.,Zhou H.,et al. Schisantherin a attenuates neuroinflammation in activated microglia: Role of Nrf2 activation through ERK phosphorylation[J]. Cellular Physiology and Biochemistry,2018,47(5):1769-1784.
APA Li C..,Chen T..,Zhou H..,Zhang C..,Feng Y..,...&Lee S.M.-Y..(2018).Schisantherin a attenuates neuroinflammation in activated microglia: Role of Nrf2 activation through ERK phosphorylation.Cellular Physiology and Biochemistry,47(5),1769-1784.
MLA Li C.,et al."Schisantherin a attenuates neuroinflammation in activated microglia: Role of Nrf2 activation through ERK phosphorylation".Cellular Physiology and Biochemistry 47.5(2018):1769-1784.
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