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Myricanol mitigates lipid accumulation in 3T3-L1 adipocytes and high fat diet-fed zebrafish via activating AMP-activated protein kinase
Shen S.2; Liao Q.2; Feng Y.2; Liu J.2; Pan R.1; Lee S.M.-Y.2; Lin L.2
2019
Source PublicationFood Chemistry
ISSN18737072 03088146
Volume270Pages:305-314
Abstract

Myricanol is a diarylheptanoid isolated from Chinese bayberry. Through virtual docking strategy, myricanol was discovered as an AMP-activated protein kinase (AMPK) activator among a series of structural analogs, with high affinity for the γ subunit of AMPK. Myricanol was also evaluated for regulatory effects on lipid accumulation and insulin sensitivity in 3T3-L1 adipocytes and adiposity in high-fat diet-fed zebrafish. Myricanol suppressed lipid accumulation in 3T3-L1 cells in the initial stage (days 0–2) by suppressing adipogenesis and in the terminal stage (days 4–7) by inducing lipolysis and lipid combustion through activating AMPK. Moreover, myricanol enhanced insulin-stimulated glucose uptake by activating the insulin signaling pathway. In high-fat diet-fed zebrafish, myricanol inhibited lipid accumulation by suppressing adipogenic factors including peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer binding protein α (C/EBPα). In summary, the results indicate that myricanol could be a potential therapeutic agent against obesity by activating the AMPK signaling pathway.

KeywordAdipogenesis Amp-activated Protein Kinase Insulin Sensitivity Lipid Accumulation Myricanol Zebrafish
DOI10.1016/j.foodchem.2018.07.117
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Nutrition & Dietetics ; Food Science & Technology
WOS SubjectChemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics
WOS IDWOS:000443253200039
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Cited Times [WOS]:12   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLin L.
Affiliation1.Institute of Medicinal Plant Development, Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100193, China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa, Macau
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Shen S.,Liao Q.,Feng Y.,et al. Myricanol mitigates lipid accumulation in 3T3-L1 adipocytes and high fat diet-fed zebrafish via activating AMP-activated protein kinase[J]. Food Chemistry,2019,270:305-314.
APA Shen S..,Liao Q..,Feng Y..,Liu J..,Pan R..,...&Lin L..(2019).Myricanol mitigates lipid accumulation in 3T3-L1 adipocytes and high fat diet-fed zebrafish via activating AMP-activated protein kinase.Food Chemistry,270,305-314.
MLA Shen S.,et al."Myricanol mitigates lipid accumulation in 3T3-L1 adipocytes and high fat diet-fed zebrafish via activating AMP-activated protein kinase".Food Chemistry 270(2019):305-314.
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