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Myricanol mitigates lipid accumulation in 3T3-L1 adipocytes and high fat diet-fed zebrafish via activating AMP-activated protein kinase
Shen S.2; Liao Q.2; Feng Y.2; Liu J.2; Pan R.1; Lee S.M.-Y.2; Lin L.2
2019
Source PublicationFood Chemistry
ISSN18737072 03088146
Volume270Pages:305-314
AbstractMyricanol is a diarylheptanoid isolated from Chinese bayberry. Through virtual docking strategy, myricanol was discovered as an AMP-activated protein kinase (AMPK) activator among a series of structural analogs, with high affinity for the γ subunit of AMPK. Myricanol was also evaluated for regulatory effects on lipid accumulation and insulin sensitivity in 3T3-L1 adipocytes and adiposity in high-fat diet-fed zebrafish. Myricanol suppressed lipid accumulation in 3T3-L1 cells in the initial stage (days 0–2) by suppressing adipogenesis and in the terminal stage (days 4–7) by inducing lipolysis and lipid combustion through activating AMPK. Moreover, myricanol enhanced insulin-stimulated glucose uptake by activating the insulin signaling pathway. In high-fat diet-fed zebrafish, myricanol inhibited lipid accumulation by suppressing adipogenic factors including peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer binding protein α (C/EBPα). In summary, the results indicate that myricanol could be a potential therapeutic agent against obesity by activating the AMPK signaling pathway.
KeywordAdipogenesis AMP-activated protein kinase Insulin sensitivity Lipid accumulation Myricanol Zebrafish
DOI10.1016/j.foodchem.2018.07.117
URLView the original
Language英語
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Chinese Academy of Medical Sciences
2.University of Macau
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Shen S.,Liao Q.,Feng Y.,et al. Myricanol mitigates lipid accumulation in 3T3-L1 adipocytes and high fat diet-fed zebrafish via activating AMP-activated protein kinase[J]. Food Chemistry,2019,270:305-314.
APA Shen S..,Liao Q..,Feng Y..,Liu J..,Pan R..,...&Lin L..(2019).Myricanol mitigates lipid accumulation in 3T3-L1 adipocytes and high fat diet-fed zebrafish via activating AMP-activated protein kinase.Food Chemistry,270,305-314.
MLA Shen S.,et al."Myricanol mitigates lipid accumulation in 3T3-L1 adipocytes and high fat diet-fed zebrafish via activating AMP-activated protein kinase".Food Chemistry 270(2019):305-314.
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