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Enhanced in vitro and in vivo uptake of a hydrophobic model drug coumarin-6 in the presence of cucurbit[7]uril
Miao X.2; Li Y.2; Wyman I.1; Lee S.M.Y.2; Macartney D.H.1; Zheng Y.2; Wang R.2
2015-07-01
Source PublicationMedChemComm
ISSN20402511 20402503
Volume6Issue:7Pages:1370-1374
Abstract

This report describes, for the first time, cucurbit[7]uril-assisted quantitative in vitro and in vivo uptake of a hydrophobic model drug, coumarin-6, by both an epithelial cell model and a zebrafish model. The transcellular delivery pathway study suggested multiple mechanisms involved, including macropinocytosis, clathrin and lipid raft-mediated endocytosis/exocytosis.

DOI10.1039/c5md00189g
URLView the original
Indexed BySCI
WOS Research AreaBiochemistry & Molecular Biology ; Pharmacology & Pharmacy
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Medicinal
WOS IDWOS:000357786200019
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被引频次[WOS]:35   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题Institute of Chinese Medical Sciences
Affiliation1.Queen's University, Kingston
2.University of Macau
First Author AffilicationUniversity of Macau
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Miao X.,Li Y.,Wyman I.,et al. Enhanced in vitro and in vivo uptake of a hydrophobic model drug coumarin-6 in the presence of cucurbit[7]uril[J]. MedChemComm,2015,6(7):1370-1374.
APA Miao X..,Li Y..,Wyman I..,Lee S.M.Y..,Macartney D.H..,...&Wang R..(2015).Enhanced in vitro and in vivo uptake of a hydrophobic model drug coumarin-6 in the presence of cucurbit[7]uril.MedChemComm,6(7),1370-1374.
MLA Miao X.,et al."Enhanced in vitro and in vivo uptake of a hydrophobic model drug coumarin-6 in the presence of cucurbit[7]uril".MedChemComm 6.7(2015):1370-1374.
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