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Supramolecular alleviation of cardiotoxicity of a small-molecule kinase inhibitor
Yang X.2; Huang Q.2; Bardelang D.1; Wang C.2; Lee S.M.Y.2; Wang R.2
2017
Source PublicationOrganic and Biomolecular Chemistry
ISSN14770520
Volume15Issue:38Pages:8046-8053
Abstract

Small-molecule kinase inhibitors (SMKIs) have been widely used in the treatment of a variety of cancers due to their clinically demonstrated efficacy. However, the use of some SMKIs, such as sorafenib (SO), has been plagued by their cardiotoxicity that has been frequently observed in treated patients. Herein we report that the encapsulation of SO by a synthetic receptor cucurbit[7]uril (CB[7]) alleviated the inherent cardiotoxicity of SO, as demonstrated in an in vivo zebrafish model. Moreover, the anti-cancer activity of SO was well preserved, upon its encapsulation by CB[7], as demonstrated by both in vitro and in vivo cancer/angiogenesis models. This discovery may provide new insights into a novel supramolecular formulation of SMKIs for the management of their side-effects.

DOI10.1039/c7ob01505d
URLView the original
Indexed BySCI
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000412826500010
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Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Institut de Chimie Radicalaire
2.University of Macau
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Yang X.,Huang Q.,Bardelang D.,et al. Supramolecular alleviation of cardiotoxicity of a small-molecule kinase inhibitor[J]. Organic and Biomolecular Chemistry,2017,15(38):8046-8053.
APA Yang X.,Huang Q.,Bardelang D.,Wang C.,Lee S.M.Y.,&Wang R..(2017).Supramolecular alleviation of cardiotoxicity of a small-molecule kinase inhibitor.Organic and Biomolecular Chemistry,15(38),8046-8053.
MLA Yang X.,et al."Supramolecular alleviation of cardiotoxicity of a small-molecule kinase inhibitor".Organic and Biomolecular Chemistry 15.38(2017):8046-8053.
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