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Structure-property correlations of reactive oxygen species-responsive and hydrogen peroxide-eliminating materials with anti-oxidant and anti-inflammatory activities
Zhang Q.1; Zhang F.2; Chen Y.1; Dou Y.1; Tao H.1; Zhang D.3; Wang R.4; Li X.2; Zhang J.1
2017-10-10
Source PublicationChemistry of Materials
ISSN15205002 08974756
Volume29Issue:19Pages:8221-8238
Abstract

To develop reactive oxygen species (ROS)-responsive anti-inflammatory materials and establish their structure-property correlations, a series of HO-eliminating materials (OxbCDs) were designed and synthesized by conjugating different phenylboronic acid pinacol ester (PBAP) groups onto a biocompatible scaffold compound β-cyclodextrin via varied linker groups. Both the HO-triggered hydrolysis profiles and HO-eliminating capacities of these materials were dependent on the chemical structure of the PBAP moieties. Together with the elucidation of hydrolysis mechanisms, we established structure-property correlations of these OxbCD materials. Extensive in vitro experiments revealed nanoparticles (NPs) based on OxbCDs showed no adverse biological effects on normal cells. OxbCD NPs could effectively inhibit inflammatory responses and oxidative stress in stimulated macrophages. Consistently, OxbCD NPs efficaciously alleviated the symptoms of peritonitis in mice, with respect to reducing the counts of neutrophils and macrophages as well as inhibiting the secretion of pro-inflammatory cytokines, chemokines, and oxidative mediators. Similarly, OxbCD NPs loaded with anti-inflammatory drugs displayed superior efficacy in an acute inflammation model of peritonitis in mice. More importantly, OxbCD NPs showed good biocompatibility after administration via different routes. Consequently, besides serving as anti-inflammatory materials, the newly developed HO-eliminating materials may be utilized as pharmacologically functional carriers for targeted therapy of many diseases associated with inflammation and oxidative stress.

DOIhttp://doi.org/10.1021/acs.chemmater.7b02412
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Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorZhang J.
Affiliation1.Department of Pharmaceutics, College of Pharmacy, Third Military Medical University, Chongqing 400038, China
2.Institute of Materia Medica, College of Pharmacy, Third Military Medical University, Chongqing 400038, China
3.Department of Chemistry, College of Pharmacy, Third Military Medical University, Chongqing 400038, China
4.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau China
Recommended Citation
GB/T 7714
Zhang Q.,Zhang F.,Chen Y.,et al. Structure-property correlations of reactive oxygen species-responsive and hydrogen peroxide-eliminating materials with anti-oxidant and anti-inflammatory activities[J]. Chemistry of Materials,2017,29(19):8221-8238.
APA Zhang Q..,Zhang F..,Chen Y..,Dou Y..,Tao H..,...&Zhang J..(2017).Structure-property correlations of reactive oxygen species-responsive and hydrogen peroxide-eliminating materials with anti-oxidant and anti-inflammatory activities.Chemistry of Materials,29(19),8221-8238.
MLA Zhang Q.,et al."Structure-property correlations of reactive oxygen species-responsive and hydrogen peroxide-eliminating materials with anti-oxidant and anti-inflammatory activities".Chemistry of Materials 29.19(2017):8221-8238.
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