UM
BHDPC Is a Novel Neuroprotectant That Provides Anti-neuroinflammatory and Neuroprotective Effects by Inactivating NF-kappa B and Activating PKA/CREB
Li, Chuwen; Chen, Tongkai; Zhou, Hefeng; Feng, Yu; Hoi, Maggie P. M.; Ma, Dan; Zhao, Chao; Zheng, Ying; Lee, Simon M. Y.
2018-06-25
Source PublicationFRONTIERS IN PHARMACOLOGY
ISSN1663-9812
Volume9
AbstractMicroglia-mediated neuroinflammatory responses are inevitable and important pathological processes in several kinds of disorder of the central nervous system (CNS). Therefore, alleviating activated microglia-induced inflammatory process might be a valuable therapeutic approach to neuroinflammation-related diseases. In the present study, we investigated BHDPC, a novel neuroprotectant discovered in our previous study that had anti-inflammatory effects under neuroinflammatory conditions. First, we found that BHDPC could inhibit neuroinflammatory responses and promote microglial M2 phenotype polarization in both lipopolysaccharide (LPS)-activated BV-2 microglia I cells. Furthermore, BHDPC provided protective actions against neuroinflammation-induced neurotoxicity in HT22 mouse hippocampal cells co-cultured with activated BV-2 microglia. Further experiments demonstrated that BHDPC could suppress LPS-induced activation of transcription factor nuclear factor kappa B (NF-kappa B) via interfering with the degradation of the inhibitor of kappa B (I kappa B) and phosphorylation of I kappa B, the I kappa B kinase (IKK). Moreover, we also found that BHDPC could induce phosphorylation of cAMP-dependent protein kinase A (PKA) and cAMP-response element-binding protein (CREB) in BV-2 microglial cells. Also, using the PKA-specific inhibitor, we found that BHDPC-induced CREB phosphorylation was dependent on PKA, which also contributed to BHDPC-mediated anti-inflammation and neuroprotection.
KeywordBHDPC neuroinflammation microglia NF-kappa B CREB PKA
DOI10.3389/fphar.2018.00614
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000436109800001
PublisherFRONTIERS MEDIA SA
The Source to ArticleWOS
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Li, Chuwen,Chen, Tongkai,Zhou, Hefeng,et al. BHDPC Is a Novel Neuroprotectant That Provides Anti-neuroinflammatory and Neuroprotective Effects by Inactivating NF-kappa B and Activating PKA/CREB[J]. FRONTIERS IN PHARMACOLOGY,2018,9.
APA Li, Chuwen.,Chen, Tongkai.,Zhou, Hefeng.,Feng, Yu.,Hoi, Maggie P. M..,...&Lee, Simon M. Y..(2018).BHDPC Is a Novel Neuroprotectant That Provides Anti-neuroinflammatory and Neuroprotective Effects by Inactivating NF-kappa B and Activating PKA/CREB.FRONTIERS IN PHARMACOLOGY,9.
MLA Li, Chuwen,et al."BHDPC Is a Novel Neuroprotectant That Provides Anti-neuroinflammatory and Neuroprotective Effects by Inactivating NF-kappa B and Activating PKA/CREB".FRONTIERS IN PHARMACOLOGY 9(2018).
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