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Inhibition of drug-induced seizure development in both zebrafish and mouse models by a synthetic nanoreceptor
Huang Q.2; Kuok K.I.2; Zhang X.2; Yue L.2; Lee S.M.Y.2; Zhang J.1; Wang R.2
2018-06-14
Source PublicationNanoscale
ISSN20403372 20403364
Volume10Issue:22Pages:10333-10336
Abstract

A synthetic nanoreceptor, cucurbit[7]uril (CB[7]), fully encapsulated pentylenetetrazol (PTZ), a seizure-inducing model drug. As a consequence of the encapsulation, the development of PTZ induced convulsion behaviors in both larval zebrafish and mouse models were dramatically alleviated, suggesting that CB[7] holds great neuroprotection potential against neurotoxic drugs for clinical applications.

DOI10.1039/c8nr02041h
URLView the original
Indexed BySCI
WOS Research AreaScience & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS IDWOS:000434692000002
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Third Military Medical University
2.University of Macau
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Huang Q.,Kuok K.I.,Zhang X.,et al. Inhibition of drug-induced seizure development in both zebrafish and mouse models by a synthetic nanoreceptor[J]. Nanoscale,2018,10(22):10333-10336.
APA Huang Q..,Kuok K.I..,Zhang X..,Yue L..,Lee S.M.Y..,...&Wang R..(2018).Inhibition of drug-induced seizure development in both zebrafish and mouse models by a synthetic nanoreceptor.Nanoscale,10(22),10333-10336.
MLA Huang Q.,et al."Inhibition of drug-induced seizure development in both zebrafish and mouse models by a synthetic nanoreceptor".Nanoscale 10.22(2018):10333-10336.
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