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Polymeric Nanomedicine with "lego" Surface Allowing Modular Functionalization and Drug Encapsulation
Sun C.3; Zhang H.1; Li S.3; Zhang X.3; Cheng Q.3; Ding Y.3; Wang L.-H.2; Wang R.3
2018-08-01
Source PublicationACS Applied Materials and Interfaces
ISSN19448252 19448244
Volume10Issue:30Pages:25090-25098
AbstractSurface functionalization of nanoparticles (NPs) is of pivotal importance in nanomedicine. However, current strategies often require covalent conjugation that involves laborious design and synthesis. Herein, cucurbit[7]uril (CB[7])-decorated poly(lactic acid) (PLA)/poly(lactic-co-glycolic acid) (PLGA) NPs are developed and exploited for the first time as a novel, biocompatible, and versatile drug delivery platform with a noncovalently tailorable surface. CB[7] on the surface of NPs, acting as a "Lego" base block, allowed facile, modular surface modification with a variety of functional moieties or tags that are linked with amantadine (a complementary "Lego" piece to the base block), including amantadine-conjugated folate, polyethylene glycol, and fluorescein isothiocyanate. In addition, surface CB[7] also provided an opportunity for encapsulation of a secondary drug, such as oxaliplatin, into the cavity of the base block CB[7], in addition to a primary drug (e.g., paclitaxel) loaded into PLA/PLGA NPs, for a possible synergistic chemotherapy. This proof of concept not only provides the first versatile PLA/PLGA nanomedicine platform with "Lego" surface for modular functionalization and improved drug delivery but also offers new insights into the design and development of novel nanomedicine with a modular surface.
Keywordcucurbituril drug delivery nanomedicine PLA/PLGA surface functionalization
DOI10.1021/acsami.8b06598
URLView the original
Language英語
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Cited Times [WOS]:14   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Jilin University
2.Nanjing University of Post and TeleCommunications
3.University of Macau
First Author AffilicationUniversity of Macau
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GB/T 7714
Sun C.,Zhang H.,Li S.,et al. Polymeric Nanomedicine with "lego" Surface Allowing Modular Functionalization and Drug Encapsulation[J]. ACS Applied Materials and Interfaces,2018,10(30):25090-25098.
APA Sun C..,Zhang H..,Li S..,Zhang X..,Cheng Q..,...&Wang R..(2018).Polymeric Nanomedicine with "lego" Surface Allowing Modular Functionalization and Drug Encapsulation.ACS Applied Materials and Interfaces,10(30),25090-25098.
MLA Sun C.,et al."Polymeric Nanomedicine with "lego" Surface Allowing Modular Functionalization and Drug Encapsulation".ACS Applied Materials and Interfaces 10.30(2018):25090-25098.
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