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A user-friendly herbicide derived from photo-responsive supramolecular vesicles
Gao C.2; Huang Q.2; Lan Q.2; Feng Y.2; Tang F.2; Hoi M.P.M.2; Zhang J.1; Lee S.M.Y.2; Wang R.2
2018-12-01
Source PublicationNature Communications
ISSN20411723
Volume9Issue:1
Abstract

Paraquat, as one of the most widely used herbicides globally, is highly toxic to humans, and chronic exposure and acute ingestion leads to high morbidity and mortality rates. Here, we report user-friendly, photo-responsive paraquat-loaded supramolecular vesicles, prepared via one-pot self-assembly of amphiphilic, ternary host-guest complexes between cucurbit[8]uril, paraquat, and an azobenzene derivative. In this vesicle formulation, paraquat is only released upon UV or sunlight irradiation that converts the azobenzene derivative from its trans- to its cis- form, which in turn dissociates the ternary host-guest complexations and the vesicles. The cytotoxicity evaluation of this vesicle formulation of paraquat on in vitro cell models, in vivo zebrafish models, and mouse models demonstrates an enhanced safety profile. Additionally, the PQ-loaded vesicles’ herbicidal activity against a model of invasive weed is nearly identical to that of free paraquat under natural sunlight. This study provides a safe yet effective herbicide formulation.

DOI10.1038/s41467-018-05437-5
URLView the original
Indexed BySCI
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000439971400008
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Cited Times [WOS]:15   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Third Military Medical University
2.University of Macau
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Gao C.,Huang Q.,Lan Q.,et al. A user-friendly herbicide derived from photo-responsive supramolecular vesicles[J]. Nature Communications,2018,9(1).
APA Gao C..,Huang Q..,Lan Q..,Feng Y..,Tang F..,...&Wang R..(2018).A user-friendly herbicide derived from photo-responsive supramolecular vesicles.Nature Communications,9(1).
MLA Gao C.,et al."A user-friendly herbicide derived from photo-responsive supramolecular vesicles".Nature Communications 9.1(2018).
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