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A systematic evaluation of the biocompatibility of cucurbit[7]uril in mice
Zhang X.3; Xu X.1; Li S.3; Wang L.-H.2; Zhang J.1; Wang R.3
2018-12-01
Source PublicationScientific Reports
ISSN20452322
Volume8Issue:1
AbstractAs one of the most water-soluble members in the macrocyclic cucurbit[n]uril (CB[n]) family, CB[7] has attracted increasing attention in pharmaceutical and biomedical fields. Despite extensive studies regarding the potential use of CB[7] for biomedical applications, its full safety and toxicity profile in a clinically relevant model is still lacking. Herein we report the full biocompatibility profile of CB[7], administered orally, peritoneally or intravenously in mice, respectively. Body-weight changes showed no significant differences among various groups of mice after they were administered with CB[7] at a single dose of 5 g/kg orally, 500 mg/kg peritoneally and 150 mg/kg intravenously, respectively. Hematology tests, as well as hepatic and renal function biochemical markers tests, of the blood collected from these mice sacrificed 21 days after CB[7] administration all exhibited normal ranges of values that were comparable with those of the control group. Moreover, histopathological analysis on the sections of major organs (including the heart, liver, spleen, lungs and kidneys) and gastrointestinal tissues revealed no detectable injuries and inflammatory cells infiltration. Taken together, these results suggest an excellent biocompatibility profile of CB[7] in mice, which provide important foundations for further investigations and even clinical applications of CB[7] in biomedical areas.
DOI10.1038/s41598-018-27206-6
URLView the original
Language英語
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Third Military Medical University
2.Nanjing University of Post and TeleCommunications
3.University of Macau
First Author AffilicationUniversity of Macau
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GB/T 7714
Zhang X.,Xu X.,Li S.,et al. A systematic evaluation of the biocompatibility of cucurbit[7]uril in mice[J]. Scientific Reports,2018,8(1).
APA Zhang X.,Xu X.,Li S.,Wang L.-H.,Zhang J.,&Wang R..(2018).A systematic evaluation of the biocompatibility of cucurbit[7]uril in mice.Scientific Reports,8(1).
MLA Zhang X.,et al."A systematic evaluation of the biocompatibility of cucurbit[7]uril in mice".Scientific Reports 8.1(2018).
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