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An analysis of chemical ingredients network of Chinese herbal formulae for the treatment of coronary heart disease
Ding F.1; Zhang Q.1,2; Ung C.O.L.1; Wang Y.1; Han Y.3; Hu Y.1; Qi J.4
2015-02-06
Source PublicationPLoS ONE
ISSN19326203
Volume10Issue:2
Abstract

As a complex system, the complicated interactions between chemical ingredients, as well as the potential rules of interactive associations among chemical ingredients of traditional Chinese herbal formulae are not yet fully understood by modern science. On the other hand, network analysis is emerging as a powerful approach focusing on processing complex interactive data. By employing network approach in selected Chinese herbal formulae for the treatment of coronary heart disease (CHD), this article aims to construct and analyze chemical ingredients network of herbal formulae, and provide candidate herbs, chemical constituents, and ingredient groups for further investigation. As a result, chemical ingredients network composed of 1588 ingredients from 36 herbs used in 8 core formulae for the treatment of CHD was produced based on combination associations in herbal formulae. In this network, 9 communities with relative dense internal connections are significantly associated with 14 kinds of chemical structures with P<0.001. Moreover, chemical structural fingerprints of network communities were detected, while specific centralities of chemical ingredients indicating different levels of importance in the network were also measured. Finally, several distinct herbs, chemical ingredients, and ingredient groups with essential position in the network or high centrality value are recommended for further pharmacology study in the context of new drug development.

DOIhttp://doi.org/10.1371/journal.pone.0116441
URLView the original
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000349444900039
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorHu Y.; Qi J.
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Av. Padre Tomás Pereira S.J., Taipa, Macao 999078, China
2.Pharmacy School, Zunyi Medical University, No.201 Dalian Road, Zunyi 563003, China
3.Department of Applied Biology & Chemical Technology, The Hong Kong Polytechnic University, 11 Yuk Choi Road, Hung Hom, Kowloon, Hong Kong 999077, China
4.4 Department of Complex Prescription of Traditional Chinese Medicine, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Ding F.,Zhang Q.,Ung C.O.L.,et al. An analysis of chemical ingredients network of Chinese herbal formulae for the treatment of coronary heart disease[J]. PLoS ONE,2015,10(2).
APA Ding F..,Zhang Q..,Ung C.O.L..,Wang Y..,Han Y..,...&Qi J..(2015).An analysis of chemical ingredients network of Chinese herbal formulae for the treatment of coronary heart disease.PLoS ONE,10(2).
MLA Ding F.,et al."An analysis of chemical ingredients network of Chinese herbal formulae for the treatment of coronary heart disease".PLoS ONE 10.2(2015).
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