UM  > 中華醫藥研究院
Bisdemethoxycurcumin Increases Sirt1 to Antagonize t-BHP-Induced Premature Senescence in WI38 Fibroblast Cells
Li, Ying-Bo1,2; Zhong, Zhang-Feng1; Chen, Mei-Wan1; Bao, Jiao-Lin1; Wu, Guo-Sheng1; Zhang, Qing-Wen1; Lee, Simon Ming-Yuen1; Hoi, Pui-Man1; Wang, Yi-Tao1
2013
Source PublicationEVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 文献号: 851714
ISSN1741-427X
Abstract

Curcuminoids are well known for their capabilities to combat risk factors that are associated with ageing and cellular senescence. Recent reports have demonstrated that curcuminoids can extend the lifespan of model organisms. However, the underlying mechanisms by which these polyphenic compounds exert these beneficial effects remain unknown. In this study, t-BHP-induced premature senescence model in human fibroblasts was chosen to explore the protective effects of a curcuminoid, bisdemethoxycurcumin (BDMC), on cellular senescence. The results demonstrated that BDMC attenuated oxidative stress-induced senescence-like features which include the induction of an enlarged cellular appearance, higher frequency of senescence-associated beta-galactosidase staining activity, appearance of senescence-associated heterochromatic foci in nuclei, decrease in proliferation capability, and alteration inrelated molecules such as p16 and retinoblastoma protein. Notably, we found that BDMC treatment activated Sirt1/AMPK signaling pathway. Moreover, downregulating Sirt1 by the pharmacological inhibitor nicotianamine or small interfering RNA blocked BDMC-mediated protection against t-BHP-mediated decrease in proliferation. These results suggested that BDMC prevented t-BHP-induced cellular senescence, and BDMC-induced Sirt1 may be a mechanism mediating its beneficial effects.

DOI10.1155/2013/851714
Indexed BySCI
Language英语
WOS Research AreaIntegrative & Complementary Medicine
WOS SubjectIntegrative & Complementary Medicine
WOS IDWOS:000324438200001
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Univ Macau, State Key Lab Qual Res Chinese Med, Inst Chinese Med Sci, Taipa 999078, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Li, Ying-Bo,Zhong, Zhang-Feng,Chen, Mei-Wan,et al. Bisdemethoxycurcumin Increases Sirt1 to Antagonize t-BHP-Induced Premature Senescence in WI38 Fibroblast Cells[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 文献号: 851714,2013.
APA Li, Ying-Bo.,Zhong, Zhang-Feng.,Chen, Mei-Wan.,Bao, Jiao-Lin.,Wu, Guo-Sheng.,...&Wang, Yi-Tao.(2013).Bisdemethoxycurcumin Increases Sirt1 to Antagonize t-BHP-Induced Premature Senescence in WI38 Fibroblast Cells.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 文献号: 851714.
MLA Li, Ying-Bo,et al."Bisdemethoxycurcumin Increases Sirt1 to Antagonize t-BHP-Induced Premature Senescence in WI38 Fibroblast Cells".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 文献号: 851714 (2013).
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li, Ying-Bo]'s Articles
[Zhong, Zhang-Feng]'s Articles
[Chen, Mei-Wan]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li, Ying-Bo]'s Articles
[Zhong, Zhang-Feng]'s Articles
[Chen, Mei-Wan]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li, Ying-Bo]'s Articles
[Zhong, Zhang-Feng]'s Articles
[Chen, Mei-Wan]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.