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Translating Current Bioanalytical Techniques for Studying Corona Activity
Wang, Chunming1; Wang, Zhenzhen2; Dong, Lei2
2018-07
Source PublicationTRENDS IN BIOTECHNOLOGY
ISSN0167-7799
Volume36Issue:7Pages:661-672
Abstract

The recent discovery of the biological corona is revolutionising our understanding of the in vivo behaviour of nanomaterials. Accurate analysis of corona bioactivity is essential for predicting the fate of nanomaterials and thereby improving nanomedicine design. Nevertheless, current biotechniques for protein analysis are not readily adaptable for analysing corona proteins, given that their conformation, activity, and interaction may largely differ from those of the native proteins. Here, we introduce and propose tailor-made modifications to five types of mainstream bioanalytical methodologies. We specifically illustrate how these modifications can translate existing techniques for protein analysis into competent tools for dissecting the composition, bioactivity, and interaction (with both nanomaterials and the tissue) of corona formed on specific nanomaterial surfaces.

DOI10.1016/j.tibtech.2018.02.016
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiotechnology & Applied Microbiology
WOS SubjectBiotechnology & Applied Microbiology
WOS IDWOS:000435199500006
PublisherELSEVIER SCIENCE LONDON
The Source to ArticleWOS
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorDong, Lei
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, China
2.State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210093, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Wang, Chunming,Wang, Zhenzhen,Dong, Lei. Translating Current Bioanalytical Techniques for Studying Corona Activity[J]. TRENDS IN BIOTECHNOLOGY,2018,36(7):661-672.
APA Wang, Chunming,Wang, Zhenzhen,&Dong, Lei.(2018).Translating Current Bioanalytical Techniques for Studying Corona Activity.TRENDS IN BIOTECHNOLOGY,36(7),661-672.
MLA Wang, Chunming,et al."Translating Current Bioanalytical Techniques for Studying Corona Activity".TRENDS IN BIOTECHNOLOGY 36.7(2018):661-672.
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