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Ganoderiol A-Enriched Extract Suppresses Migration and Adhesion of MDA-MB-231 Cells by Inhibiting FAK-SRC-Paxillin Cascade Pathway
Wu, Guo-Sheng1; Song, YL (Song, Yue-Lin)1; Yin, Zhi-Qi2; Guo, Jia-Jie1; Wang, Sheng-Peng1; Zhao, Wen-Wen1; Chen, Xiu-Ping1; Zhang, Qing-Wen1; Lu, Jin-Jian1; Wang, Yi-Tao1
2013-10-29
Source PublicationPLOS ONE
ISSN1932-6203
Volume8Issue:10
Abstract

Cell adhesion, migration and invasion are critical steps for carcinogenesis and cancer metastasis. Ganoderma lucidum, also called Lingzhi in China, is a traditional Chinese medicine, which exhibits anti-proliferation, anti-inflammation and anti-metastasis properties. Herein, GAEE, G. lucidum extract mainly contains ganoderiol A (GA), dihydrogenated GA and GA isomer, was shown to inhibit the abilities of adhesion and migration, while have a slight influence on that of invasion in highly metastatic breast cancer MDA-MB-231 cells at non-toxic doses. Further investigation revealed that GAEE decreased the active forms of focal adhesion kinase (FAK) and disrupted the interaction between FAK and SRC, which lead to deactivating of paxillin. Moreover, GAEE treatment downregulated the expressions of RhoA, Rac1, and Cdc42, and decreased the interaction between neural Wiskott-Aldrich Syndrome protein (N-WASP) and Cdc42, which impair cell migration and actin assembly. To our knowledge, this is the first report to show that G. lucidum triterpenoids could suppress cell migration and adhesion through FAK-SRC-paxillin signaling pathway. Our study also suggests that GAEE may be a potential agent for treatment of breast cancer.

DOI10.1371/journal.pone.0076620
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000326270700008
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:26   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Taipa, Peoples R China
2.China Pharmaceut Univ, Dept Nat Med Chem, Nanjing, Jiangsu, Peoples R China
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Wu, Guo-Sheng,Song, YL ,Yin, Zhi-Qi,et al. Ganoderiol A-Enriched Extract Suppresses Migration and Adhesion of MDA-MB-231 Cells by Inhibiting FAK-SRC-Paxillin Cascade Pathway[J]. PLOS ONE,2013,8(10).
APA Wu, Guo-Sheng.,Song, YL .,Yin, Zhi-Qi.,Guo, Jia-Jie.,Wang, Sheng-Peng.,...&Wang, Yi-Tao.(2013).Ganoderiol A-Enriched Extract Suppresses Migration and Adhesion of MDA-MB-231 Cells by Inhibiting FAK-SRC-Paxillin Cascade Pathway.PLOS ONE,8(10).
MLA Wu, Guo-Sheng,et al."Ganoderiol A-Enriched Extract Suppresses Migration and Adhesion of MDA-MB-231 Cells by Inhibiting FAK-SRC-Paxillin Cascade Pathway".PLOS ONE 8.10(2013).
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