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Panax notoginseng saponins protect against chronic ethanol-induced hepatic steatosis
Ding Renbo; Bao Jiaolin; Cao Yiwei; He Chengwei; Wang Yitao; Wan Jianbo
2014
Source PublicationJournal of Chinese Pharmaceutical Sciences
ISSN1003-1057
Volume23Issue:6Pages:361-368
Abstract

Chronic alcohol consumption induces hepatic steatosis, the early stage of alcoholic liver disease (ALD). The aim of present study is to investigate the protective effect of Panax notoginseng saponins (PNS) against chronic ethanol-induced hepatic steatosis in vivo. Mice were pair-fed a modified Lieber-DeCarli liquid diet containing alcohol or isocaloric maltose dextrin as control diet with or without PNS (200 mg/kg, BW) for 8 weeks. Animals supplemented with PNS were protected against hepatic lipid accumulation induced by chronic ethanol exposure. Accordingly, PNS could significantly decrease the elevation of plasma triglyceride, plasma enzyme activities, i.e. alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and hepatic TNF-alpha and IL-6 levels which were induced by chronic alcohol exposure. In addition, PNS markedly reduced the lipolysis of white adipose tissue (WAT) that stimulated by alcohol feeding through the inhibiting protein expression of phosphorylation of hormonesensitive lipase (p-HSL), rather than total HSL. Furthermore, alcohol exposure also enhanced fatty acid uptake capacity in liver by elevated hepatic CD36 expression, which could attenuated by PNS treatment. These results demonstrate that PNS supplementation protects against chronic ethanolinduced hepatic steatosis, which is associated with ameliorating dysfunctional lipid metabolism of WAT and the reduced inflammatory cytokines. Our findings suggested that PNS might be potential to be developed as an effective agent for the treatment of chronic alcoholic steatosis.

KeywordAlcoholic Fatty Liver Panax Notoginseng Saponins Lipolysis Inflammation
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
CSCD IDCSCD:5195455
The Source to ArticleWOS
Fulltext Access
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
AffiliationInstitute of Chinese Medical Sciences, University of Macau, State Key Laboratory of Quality Research in Chinese Medicine, 999078, Macao.
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Ding Renbo,Bao Jiaolin,Cao Yiwei,et al. Panax notoginseng saponins protect against chronic ethanol-induced hepatic steatosis[J]. Journal of Chinese Pharmaceutical Sciences,2014,23(6):361-368.
APA Ding Renbo,Bao Jiaolin,Cao Yiwei,He Chengwei,Wang Yitao,&Wan Jianbo.(2014).Panax notoginseng saponins protect against chronic ethanol-induced hepatic steatosis.Journal of Chinese Pharmaceutical Sciences,23(6),361-368.
MLA Ding Renbo,et al."Panax notoginseng saponins protect against chronic ethanol-induced hepatic steatosis".Journal of Chinese Pharmaceutical Sciences 23.6(2014):361-368.
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