UM  > 中華醫藥研究院
Biological activities and potential molecular targets of cucurbitacins: a focus on cancer
Chen, XP (Chen, Xiuping); Bao, JL (Bao, Jiaolin); Guo, JJ (Guo, Jiajie); Ding, Q (Ding, Qian); Lu, JJ (Lu, Jinjian); Huang, MQ (Huang, Mingqing); Wang, YT (Wang, Yitao)
2012-09-01
Source PublicationANTI-CANCER DRUGS
Volume23Issue:8Pages:777-787
Abstract

Cucurbitacin and its derivatives (cucurbitacins) are a class of highly oxidized tetracyclic triterpenoids. They are widely distributed in the plant kingdom, where they act as heterologous chemical pheromones that protect plants from external biological insults. Their bioactivities first attracted attention in the 1960s. Documented data demonstrate that cucurbitacins possess strong pharmacological properties, such as antitumor, anti-inflammatory, and hepatoprotective effects, etc. Several molecular targets for cucurbitacins have been discovered, such as fibrous-actin, signal transducer and activator of transcription 3, cyclooxygenase-2, etc. The present study summarizes the achievements of the 50 years of research on cucurbitacins. The aim was to systematically analyze their bioactivities with an emphasis on their anticancer effects. Research and development has shed new insight into the beneficial properties of these compounds. Anti-Cancer Drugs 23: 777-787 (C) 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins.

KeywordCell-cycle Arrest Cell-cycle Arrest Bryonia-alba l Pancreatic-cancer Inhibitory-activity Antitumor-activity Signaling Pathway Leukemia-cells Melanoma-cells In-vitro
Indexed BySCI
WOS Research AreaOncology ; Pharmacology & Pharmacy
WOS SubjectOncology ; Pharmacology & Pharmacy
WOS IDWOS:000306706000002
Fulltext Access
Citation statistics
Cited Times [WOS]:70   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
AffiliationUniversity of Macau
Recommended Citation
GB/T 7714
Chen, XP ,Bao, JL ,Guo, JJ ,et al. Biological activities and potential molecular targets of cucurbitacins: a focus on cancer[J]. ANTI-CANCER DRUGS,2012,23(8):777-787.
APA Chen, XP .,Bao, JL .,Guo, JJ .,Ding, Q .,Lu, JJ .,...&Wang, YT .(2012).Biological activities and potential molecular targets of cucurbitacins: a focus on cancer.ANTI-CANCER DRUGS,23(8),777-787.
MLA Chen, XP ,et al."Biological activities and potential molecular targets of cucurbitacins: a focus on cancer".ANTI-CANCER DRUGS 23.8(2012):777-787.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Chen, XP (Chen, Xiuping)]'s Articles
[Bao, JL (Bao, Jiaolin)]'s Articles
[Guo, JJ (Guo, Jiajie)]'s Articles
Baidu academic
Similar articles in Baidu academic
[Chen, XP (Chen, Xiuping)]'s Articles
[Bao, JL (Bao, Jiaolin)]'s Articles
[Guo, JJ (Guo, Jiajie)]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Chen, XP (Chen, Xiuping)]'s Articles
[Bao, JL (Bao, Jiaolin)]'s Articles
[Guo, JJ (Guo, Jiajie)]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.