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Polymeric micelles drug delivery system in oncology
Gong, J (Gong, Jian); Chen, MW (Chen, Meiwan); Zheng, Y (Zheng, Ying); Wang, SP (Wang, Shengpeng; Wang, YT (Wang, Yitao)
2012-03-10
Source PublicationJOURNAL OF CONTROLLED RELEASE
Volume159Issue:3Pages:312-323
Abstract

Polymeric micelles (PM) system, as an efficient drug carrier, has received growing scientific attention in recent years owing to its solubilization, selective targeting, P-glycoprotein inhibition and altered drug internalization route and subcellular localization properties. Seven PM formulations of anti-tumor drugs being evaluated in clinical trials are reviewed in this paper, in terms of formulation study, in vitro cytotoxicity, in vivo pharmacokinetics, anti-tumor efficacy and safety as well as clinical trials, to shed new light on the discovery of novel PM formulations. In these seven PM formulations, PM system was employed to overcome the issues of low water solubility, high toxicity and (or) multidrug resistance accompanied with the conventional formulation, which greatly hampered their clinical application. Those promising preclinical and clinical results combined with rapid advancement and intense multidisciplinary collaboration enable the extension of the PM system to traditional Chinese medicine, imaging agents, gene and combination agent deliveries as well as some other administration routes, which facilitate the clinical translation of the PM drug delivery system. Crown Copyright (C) 2012 Published by Elsevier B.V. All rights reserved.

KeywordAccelerated Blood Clearance Cell Lung-cancer Pegylated Liposomal Doxorubicin Albumin-bound Paclitaxel Acid) Block-copolymer Phase-ii Trial Metastatic Breast-cancer Metal Complex Micelle In-vivo Evaluation Antitumor-activity
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS SubjectChemistry, Multidisciplinary ; Pharmacology & Pharmacy
WOS IDWOS:000305001600002
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Cited Times [WOS]:292   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
AffiliationUniversity of Macau
Recommended Citation
GB/T 7714
Gong, J ,Chen, MW ,Zheng, Y ,et al. Polymeric micelles drug delivery system in oncology[J]. JOURNAL OF CONTROLLED RELEASE,2012,159(3):312-323.
APA Gong, J ,Chen, MW ,Zheng, Y ,Wang, SP ,&Wang, YT .(2012).Polymeric micelles drug delivery system in oncology.JOURNAL OF CONTROLLED RELEASE,159(3),312-323.
MLA Gong, J ,et al."Polymeric micelles drug delivery system in oncology".JOURNAL OF CONTROLLED RELEASE 159.3(2012):312-323.
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