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A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs
Sun, YY; Xun, KL; Wang, YT; Chen, XP
2009
Source PublicationANTI-CANCER DRUGS
Volume20Issue:9Pages:757-769
Abstract

Natural products represent a rich reservoir of potential small chemical molecules exhibiting anti proliferation and anticancer properties. An example is berberine, a protoberberine alkaloid widely distributed in medical plants used in traditional Chinese prescriptions. Recent advances have shown that berberine exerts anticancer activities both in vitro and in vivo through different mechanisms. Berberine shows inhibitory effects on the proliferation and reproduction of certain tumorigenic microorganisms and viruses, such as Heliobacter pylori and hepatitis B virus. Transcriptional regulation of some oncogene and carcinogenesis-related gene expression and interaction with both DNA and RNA are also well documented. Besides, berberine is a broad spectrum enzyme inhibitor, which affects N-acetyltransferase, cyclooxygenase-2, and topoisomerase activities and gene/protein expression. These actions, together with the regulation of reactive oxygen species production, mitochondrial transmembrane potential, and nuclear factor-kappa B activation might underlie its anti proliferative and proapoptotic effects. More importantly, the suppression of tumor growth and metastasis, the beneficial application in combined medication, and the improvement of multidrug resistance both in vivo and in vitro clearly show its potential as an alternative medicine for tumor chemotherapy. Anti-Cancer Drugs 20:757-769 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

KeywordApoptosis Berberine Cancer Enzyme Proliferation
DOI10.1097/CAD.0b013e328330d95b
URLView the original
Indexed BySCI
Language英语
WOS Research AreaOncology ; Pharmacology & Pharmacy
WOS SubjectOncology ; Pharmacology & Pharmacy
WOS IDWOS:000269814500001
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Cited Times [WOS]:218   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Chengdu Med Coll, Sch Pharm, Chengdu, Peoples R China
2.Peoples Hosp Binzhou, Dept Dermatol, Binzhou, Peoples R China
3.Univ Macau, Inst Chinese Med Sci, Macau, Peoples R China
Recommended Citation
GB/T 7714
Sun, YY,Xun, KL,Wang, YT,et al. A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs[J]. ANTI-CANCER DRUGS,2009,20(9):757-769.
APA Sun, YY,Xun, KL,Wang, YT,&Chen, XP.(2009).A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs.ANTI-CANCER DRUGS,20(9),757-769.
MLA Sun, YY,et al."A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs".ANTI-CANCER DRUGS 20.9(2009):757-769.
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