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Terpenoids: natural products for cancer therapy
Huang, M (Huang, Min); Lu, JJ (Lu, Jin-Jian); Huang, MQ (Huang, Ming-Qing); Bao, JL (Bao, Jiao-Lin); Chen, XP (Chen, Xiu-Ping); Wang, YT (Wang, Yi-Tao)
2012-12-01
Source PublicationEXPERT OPINION ON INVESTIGATIONAL DRUGS
Volume21Issue:12Pages:1801-1818
Abstract

Introduction: Terpenoids constitute the largest class of natural products and are a rich reservoir of candidate compounds for drug discovery. Recent efforts into the research and development of anti-cancer drugs derived from natural products have led to the identification of a variety of terpenoids that inhibit cancer cell proliferation and metastasis via various mechanisms. Despite the increasing number of research reports, there lacks a comprehensive review of anti-cancer activity of terpenoids. 

Areas covered: The present article provides an overview of the recent progress in the anti-cancer studies on terpenoids. Over a dozen naturally originated terpenoid compounds, in particular those derived from traditional Chinese medicine, were classified into five categories according to the structures, namely monoterpenoids, sesquiterpenoids, diterpenoids, triterpenoids and tetraterpenoids. The anti-cancer activities and relevant mechanistic insights of these compounds are discussed in this review. 

Expert opinion: The anti-cancer activity of terpenoids appears promising and will potentially open more opportunities for cancer therapy. However, current studies are restricted to descriptive findings and lack mechanistic insights and systematic structure-activity relationship (SAR) studies. Future efforts into the systematic identification of the targets of terpenoids are believed to increase chances of gaining breakthrough insights in the field.

KeywordNf-kappa-b Cells In-vitro Human Breast-cancer Pseudolaric-acid-b Dihydroartemisinin Induces Apoptosis Fibrosarcoma L929 Cells Hypoxia-inducible Factor-1-alpha Hepatocellular-carcinoma Cells Lycopene Inhibits Angiogenesis Oridonin-induced Apoptosis
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000310886700005
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Citation statistics
Cited Times [WOS]:87   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
AffiliationUniversity of Macau
Recommended Citation
GB/T 7714
Huang, M ,Lu, JJ ,Huang, MQ ,et al. Terpenoids: natural products for cancer therapy[J]. EXPERT OPINION ON INVESTIGATIONAL DRUGS,2012,21(12):1801-1818.
APA Huang, M ,Lu, JJ ,Huang, MQ ,Bao, JL ,Chen, XP ,&Wang, YT .(2012).Terpenoids: natural products for cancer therapy.EXPERT OPINION ON INVESTIGATIONAL DRUGS,21(12),1801-1818.
MLA Huang, M ,et al."Terpenoids: natural products for cancer therapy".EXPERT OPINION ON INVESTIGATIONAL DRUGS 21.12(2012):1801-1818.
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