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Adiponectin, an Unlocking Adipocytokine
Sun, YY; Xun, KL; Wang, CG; Zhao, HY; Bi, HC; Chen, XP; Wang, YT
2009
Source PublicationCARDIOVASCULAR THERAPEUTICS
Volume27Issue:1Pages:59-75
Abstract

A large number of studies revealed that adiponectin, a protein secreted specifically by adipose tissue, exhibits antiinflammatory, antiatherogenic, and antidiabetic properties. This 247-amino acid protein contains four differentiable domains and exists in five different configurations, which binds three kinds of receptors. The plasma adiponectin concentration is at amazing microgram level and the gender difference is very clear. Obese subjects showed decreased plasma level of adiponectin while exercise seems to restore it. Many researchers demonstrated that it could be a reliable biomarker for multiple diseases. However, there is controversy about its role in inflammation since its plasma concentration decreases in some inflammatory diseases and increases under some other inflammatory conditions. The signal transduction pathway is still not very clear yet. Could adiponectin be a promising drug target ?.

KeywordAdiponecitn Biomarker Drug Target Exercise Gender Difference Inflammation
DOI10.1111/j.1755-5922.2008.00069.x
URLView the original
Indexed BySCI
Language英语
WOS Research AreaCardiovascular System & Cardiology ; Pharmacology & Pharmacy
WOS SubjectCardiac & Cardiovascular Systems ; Pharmacology & Pharmacy
WOS IDWOS:000263243400009
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Cited Times [WOS]:56   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Chengdu Med Coll, Sch Pharm, Chengdu, Peoples R China
2.Peoples Hosp Binzhou, Dept Dermatol, Binzhou, Peoples R China
3.Univ Macau, Inst Chinese Med Sci, Macao, Peoples R China
Recommended Citation
GB/T 7714
Sun, YY,Xun, KL,Wang, CG,et al. Adiponectin, an Unlocking Adipocytokine[J]. CARDIOVASCULAR THERAPEUTICS,2009,27(1):59-75.
APA Sun, YY.,Xun, KL.,Wang, CG.,Zhao, HY.,Bi, HC.,...&Wang, YT.(2009).Adiponectin, an Unlocking Adipocytokine.CARDIOVASCULAR THERAPEUTICS,27(1),59-75.
MLA Sun, YY,et al."Adiponectin, an Unlocking Adipocytokine".CARDIOVASCULAR THERAPEUTICS 27.1(2009):59-75.
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