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TNF-alpha, a potent lipid metabolism regulator
Chen, XP; Xun, KL; Chen, LD; Wang, YT
2009
Source PublicationCELL BIOCHEMISTRY AND FUNCTION
Volume27Issue:7Pages:407-416
Abstract

As a multifunctional cytokine, tumor necrosis factor alpha (TNF-alpha) exerts a series of biological actions in different cells, tissues, organs, and species and has been demonstrated to regulate and interfere with energy metabolism, especially lipid homeostasis. A large body of researches suggested that the effects of TNF-alpha on lipid metabolism mainly include five aspects: ( I) Suppresses free fatty acid (FFA) uptake and promotes lipogenesis; (2) induces lipolysis; (3) inhibits lipid-metabolism-related enzymes activity, (4) regulates cholesterol metabolism; (5) regulates other adipocyte-derived adipokines. The molecular mechanisms underlying these actions are complex and several signal transduction pathways might be involved. Regulation of metabolism-related gene expression at transcriptional and protein levels and impact on enzymes activity might be of importance. Identification and verification of these pathways might provide novel potential strategies and drug targets for dyslipidemia therapy. However, the inconsistent and even conflict conclusions on lipid profile drawn from human subjects after infliximab therapy poses the possibility that the effect of TNF-alpha oil lipid metabolism might be more complicated than it appeared to be. Copyright (C) 2009 John Wiley & Sons, Ltd.

KeywordTumor Necrosis Factor Alpha Free Fatty Acid Lipolysis Cholesterol Leptin Adiponectin Infliximab
DOI10.1002/cbf.1596
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Cell Biology
WOS SubjectBiochemistry & Molecular Biology ; Cell Biology
WOS IDWOS:000271078000001
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Cited Times [WOS]:94   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Fujian Coll Tradit Chinese Med, Fuzhou, Peoples R China
2.Univ Macau, Inst Chinese Med Sci, Macao, Peoples R China
3.Peoples Hosp Binzhou, Dept Dermatol, Binzhou, Peoples R China
Recommended Citation
GB/T 7714
Chen, XP,Xun, KL,Chen, LD,et al. TNF-alpha, a potent lipid metabolism regulator[J]. CELL BIOCHEMISTRY AND FUNCTION,2009,27(7):407-416.
APA Chen, XP,Xun, KL,Chen, LD,&Wang, YT.(2009).TNF-alpha, a potent lipid metabolism regulator.CELL BIOCHEMISTRY AND FUNCTION,27(7),407-416.
MLA Chen, XP,et al."TNF-alpha, a potent lipid metabolism regulator".CELL BIOCHEMISTRY AND FUNCTION 27.7(2009):407-416.
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