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Research and development of anti-Alzheimer’s drugs: an analysis based on technology flows measured by patent citations
Xu, Jiachen; Kong, Xiangjun; Qiu, Lan; Geng, Xiaomei; Hu, Yuanjia; Wang, Yitao
2014-07
Source PublicationEXPERT OPINION ON THERAPEUTIC PATENTS
ISSN1354-3776
Volume24Issue:7Pages:791-800
Abstract

Introduction: Alzheimer's disease (AD) is a serious illness with dramatically increasing incidence. Tremendous worldwide efforts have been exerted to find better ways to treat the disease, delay its onset and prevent it from progressing. In order to discover future anti-AD medicines more rationally, it is crucial to understand the evolving process of existing related technologies from the perspective of technology flow. 

Areas covered: Patent citation has been used broadly as a powerful tool to capture technology flows. This study collects patent data from IMS Health databases on anti-AD drugs, both marketed and in the research and development (R&D) pipeline. In all, 329 US patents from 1978 through 2013 and citationsbetween them are analyzed, in addition to patents related to marketed drugs. 

Expert opinion: To discover effective agents for AD treatment, one promising strategy is to integrate various technology clusters related to anti-AD drugs in terms of the extremely dispersed patent citation network in this area. In this context, governments should pay more attention to encourage basic research, especially to focus on cross-mechanism anti-AD agents. New theories and targets for AD, such as the tau protein hypothesis, are worthy of researcher note. Drugs targeting beta-amyloid peptide theory show promise for investors.

KeywordAlzheimer's Disease Patent Citation Network Research And Development Technology Cluster Technology Flow
DOI10.1517/13543776.2014.915943
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000337912900006
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:11   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
AffiliationUniv Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Xu, Jiachen,Kong, Xiangjun,Qiu, Lan,et al. Research and development of anti-Alzheimer’s drugs: an analysis based on technology flows measured by patent citations[J]. EXPERT OPINION ON THERAPEUTIC PATENTS,2014,24(7):791-800.
APA Xu, Jiachen,Kong, Xiangjun,Qiu, Lan,Geng, Xiaomei,Hu, Yuanjia,&Wang, Yitao.(2014).Research and development of anti-Alzheimer’s drugs: an analysis based on technology flows measured by patent citations.EXPERT OPINION ON THERAPEUTIC PATENTS,24(7),791-800.
MLA Xu, Jiachen,et al."Research and development of anti-Alzheimer’s drugs: an analysis based on technology flows measured by patent citations".EXPERT OPINION ON THERAPEUTIC PATENTS 24.7(2014):791-800.
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