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Alkaloids Isolated from Natural Herbs as the Anticancer Agents
Lu, JJ (Lu, Jin-Jian); Bao, JL (Bao, Jiao-Lin); Chen, XP (Chen, Xiu-Ping); HHuang, M (Huang, Min); Wang, YT (Wang, Yi-Tao)
2012-09-28
Source PublicationEVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
Issue4Pages:623-644
Abstract

Alkaloids are important chemical compounds that serve as a rich reservoir for drug discovery. Several alkaloids isolated from natural herbs exhibit antiproliferation and antimetastasis effects on various types of cancers both in vitro and in vivo. Alkaloids, such as camptothecin and vinblastine, have already been successfully developed into anticancer drugs. This paper focuses on the naturally derived alkaloids with prospective anticancer properties, such as berberine, evodiamine, matrine, piperine, sanguinarine, and tetrandrine, and summarizes the mechanisms of action of these compounds. Based on the information in the literature that is summarized in this paper, the use of alkaloids as anticancer agents is very promising, but more research and clinical trials are necessary before final recommendations on specific alkaloids can be made.

KeywordCell-cycle Arrest Sanguinarine-induced Apoptosis Suppresses Tumor-growth Swiss Albino Mice Matrine Inhibits Proliferation Hepatocellular-carcinoma Cells Mediated Multidrug-resistance Buccal Pouch Carcinogenesis Berberine-induced Apoptosis Induced Lung Carcinogenesis
Indexed BySCI
Language英语
WOS Research AreaIntegrative & Complementary Medicine
WOS SubjectIntegrative & Complementary Medicine
WOS IDWOS:000308765000001
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Cited Times [WOS]:78   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
AffiliationUniversity of Macau
Recommended Citation
GB/T 7714
Lu, JJ ,Bao, JL ,Chen, XP ,et al. Alkaloids Isolated from Natural Herbs as the Anticancer Agents[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2012(4):623-644.
APA Lu, JJ ,Bao, JL ,Chen, XP ,HHuang, M ,&Wang, YT .(2012).Alkaloids Isolated from Natural Herbs as the Anticancer Agents.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE(4),623-644.
MLA Lu, JJ ,et al."Alkaloids Isolated from Natural Herbs as the Anticancer Agents".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE .4(2012):623-644.
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