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Anti-cancer properties of terpenoids isolated from Rhizoma Curcumae - A review
Lu, JJ (Lu, Jin-Jian); Dang, YY (Dang, Yuan-Ye); Huang, M (Huang, Min); Xu, WS (Xu, Wen-Shan); Chen, XP (Chen, Xiu-Ping); Wang, YT (Wang, Yi-Tao)
2012-09-28
Source PublicationJOURNAL OF ETHNOPHARMACOLOGY
Volume143Issue:2Pages:406-411
Abstract

Ethnopharmacological relevance: Rhizoma Curcumae is a popular type of traditional Chinese medicine whose essential oils are widely used in the treatment of cancer in China. This review aims to systematically summarize and analyze the anti-cancer properties of terpenoids, the main components of essential oils in Rhizoma Curcumae, and thus enable the development of new anti-cancer drugs. 

Materials and methods: Information on the recent progress of anti-cancer studies on terpenoids isolated from Rhizoma Curcumae, including beta-elemene, delta-elemene, furanodiene, furanodienone, curcumol, and germacrone, was gathered and analyzed. 

Results: Among these terpenoids, beta-elemene is the most widely studied, whereas delta-elemene, furanodiene, furanodienone, curcumol, and germacrone have just recently attracted the attention of researchers. The anti-cancer effects of these terpenoids are related to the retardation of cell cycle arrest, the induction of apoptosis, and the inhibition of metastasis or tissue invasion, among others. 

Conclusions: Most studies have focused on the in vitro data, and in vivo data is urgently needed. Further insight into the anti-cancer activity and the molecular basis of these compounds, combined with efforts in pharmaceutical chemistry and/or pharmaceutics, will potentially enable the development of new anti-cancer agents. (c) 2012 Elsevier Ireland Ltd. All rights reserved.

KeywordCell-cycle Arrest Chromatography-mass-spectrometry Human Lung-carcinoma Breast-cancer Cells Beta-elemene Delta-elemene In-vitro D-galactosamine/lipopolysaccharide Inhibitory-activity Glioblastoma Cells
Indexed BySCI
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS IDWOS:000309485000003
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Cited Times [WOS]:91   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
AffiliationUniversity of Macau
Recommended Citation
GB/T 7714
Lu, JJ ,Dang, YY ,Huang, M ,et al. Anti-cancer properties of terpenoids isolated from Rhizoma Curcumae - A review[J]. JOURNAL OF ETHNOPHARMACOLOGY,2012,143(2):406-411.
APA Lu, JJ ,Dang, YY ,Huang, M ,Xu, WS ,Chen, XP ,&Wang, YT .(2012).Anti-cancer properties of terpenoids isolated from Rhizoma Curcumae - A review.JOURNAL OF ETHNOPHARMACOLOGY,143(2),406-411.
MLA Lu, JJ ,et al."Anti-cancer properties of terpenoids isolated from Rhizoma Curcumae - A review".JOURNAL OF ETHNOPHARMACOLOGY 143.2(2012):406-411.
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