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Multi-Target Drugs: The Trend of Drug Research and Development
Lu, JJ (Lu, Jin-Jian); Pan, W (Pan, Wei); Hu, YJ (Hu, Yuan-Jia); Wang, YT (Wang, Yi-Tao
2012-06-29
Source PublicationPLOS ONE
Volume7Issue:6Pages:30-46
Abstract

Summarizing the status of drugs in the market and examining the trend of drug research and development is important in drug discovery. In this study, we compared the drug targets and the market sales of the new molecular entities approved by the U. S. Food and Drug Administration from January 2000 to December 2009. Two networks, namely, the target-target and drug-drug networks, have been set up using the network analysis tools. The multi-target drugs have much more potential, as shown by the network visualization and the market trends. We discussed the possible reasons and proposed the rational strategies for drug research and development in the future.

KeywordCancer-therapy Alzheimers-disease Parkinsons-disease Attractive Target Natural-products b Inhibitors Discovery Atherosclerosis Acetylcholinesterase Proliferation
DOIhttp://doi.org/10.1371/journal.pone.0040262
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000305892100240
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Cited Times [WOS]:153   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorHu, YJ (Hu, Yuan-Jia); Wang, YT (Wang, Yi-Tao
AffiliationState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau SAR, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Lu, JJ ,Pan, W ,Hu, YJ ,et al. Multi-Target Drugs: The Trend of Drug Research and Development[J]. PLOS ONE,2012,7(6):30-46.
APA Lu, JJ ,Pan, W ,Hu, YJ ,&Wang, YT .(2012).Multi-Target Drugs: The Trend of Drug Research and Development.PLOS ONE,7(6),30-46.
MLA Lu, JJ ,et al."Multi-Target Drugs: The Trend of Drug Research and Development".PLOS ONE 7.6(2012):30-46.
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