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Cyanidin-3-glucoside inhibits UVB-induced oxidative damage and inflammation by regulating MAP kinase and NF-kappa B signaling pathways in SKH-1 hairless mice skin
Pratheeshkumar, Poyil1,2; Son, Young-Ok1,2; Wang, Xin1,2; Divya, Sasidharan Padmaja1,2; Joseph, Binoy3,4; Hitron, John Andrew1,2; Wang, Lei1,2; Kim, Donghern2; Yin, Yuanqin2,5; Roy, Ram Vinod1,2; Lu, Jian2,6; Zhang, Zhuo2; Wang, Yitao7; Shi, Xiang Lin1,2
2014-10-01
Source PublicationTOXICOLOGY AND APPLIED PHARMACOLOGY
Volume280Issue:1Pages:127-137
Abstract

Skin cancer is one of the most commonly diagnosed cancers in the United States. Exposure to ultraviolet-B (UVB) radiation induces inflammation and photocarcinogenesis in mammalian skin. Cyanidin-3-glucoside (C3G), a member of the anthocyanin family, is present in various vegetables and fruits especially in edible berries, and displays potent antioxidant and anticarcinogenic properties. In this study, we have assessed the in vivo effects of C3G on UVB irradiation induced chronic inflammatory responses in SKH-1 hairless mice, a well-established model for UVB-induced skin carcinogenesis. Here, we show that C3G inhibited UVB-induced skin damage and inflammation in SKH-1 hairless mice. Our results indicate that C3G inhibited glutathione depletion, lipid peroxidation and myeloperoxidation in mouse skin by chronic UVB exposure. C3G significantly decreased the production of UVB-induced pro-inflammatory cytokines, such as IL-6 and TNF-alpha, associated with cutaneous inflammation. Likewise, UVB-induced inflammatory responses were diminished by C3G as observed by a remarkable reduction in the levels of phosphorylated MAP kinases, Erk1/2, p38, JNK1/2 and MKK4. Furthermore, C3G also decreased UVB-induced cyclooxygenase-2 (COX-2), PGE(2) and iNOS levels, which are well-known key mediators of inflammation and cancer. Treatment with C3G inhibited UVB-induced nuclear translocation of NF-kappa B and degradation of IKB alpha in mice skin. Immunofluorescence assay revealed that topical application of C3G inhibited the expression of 8-hydroxy-2'-deoxyguanosine, proliferating cell nuclear antigen, and cyclin D1 in chronic UVB exposed mouse skin. Collectively, these data indicates that C3G can provide substantial protection against the adverse effects of UVB radiation by modulating UVB-induced MAP kinase and NF-kappa B signaling pathways. (C) 2014 Elsevier Inc. All rights reserved.

KeywordCyanidin-3-glucoside Ultraviolet Radiation Inflammation Cox-2 Nf-kappa b
DOI10.1016/j.taap.2014.06.028
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy ; Toxicology
WOS SubjectPharmacology & Pharmacy ; Toxicology
WOS IDWOS:000342531200015
PublisherACADEMIC PRESS INC ELSEVIER SCIENCE
The Source to ArticleWOS
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Citation statistics
Cited Times [WOS]:30   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.1,Univ Kentucky, Ctr Res Environm Dis, Lexington, KY 40536 USA
2.2,Univ Kentucky, Grad Ctr Toxicol, Lexington, KY 40536 USA
3.3,Univ Kentucky, Spinal Cord & Brain Injury Res Ctr, Lexington, KY 40536 USA
4.4 ,Univ Kentucky, Dept Physiol, Lexington, KY 40536 USA
5.5, China Med Univ, Inst Canc, Affiliated Hosp 1, Shenyang, Peoples R China
6.6,Jiangsu Univ, Inst Life Sci, Zhenjiang 212013, Jiangsu, Peoples R China
7.7,Univ Macau, State Key Lab Qual Res Chinese Med, Inst Chinese Med Sci, Macao, Peoples R China
Recommended Citation
GB/T 7714
Pratheeshkumar, Poyil,Son, Young-Ok,Wang, Xin,et al. Cyanidin-3-glucoside inhibits UVB-induced oxidative damage and inflammation by regulating MAP kinase and NF-kappa B signaling pathways in SKH-1 hairless mice skin[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY,2014,280(1):127-137.
APA Pratheeshkumar, Poyil.,Son, Young-Ok.,Wang, Xin.,Divya, Sasidharan Padmaja.,Joseph, Binoy.,...&Shi, Xiang Lin.(2014).Cyanidin-3-glucoside inhibits UVB-induced oxidative damage and inflammation by regulating MAP kinase and NF-kappa B signaling pathways in SKH-1 hairless mice skin.TOXICOLOGY AND APPLIED PHARMACOLOGY,280(1),127-137.
MLA Pratheeshkumar, Poyil,et al."Cyanidin-3-glucoside inhibits UVB-induced oxidative damage and inflammation by regulating MAP kinase and NF-kappa B signaling pathways in SKH-1 hairless mice skin".TOXICOLOGY AND APPLIED PHARMACOLOGY 280.1(2014):127-137.
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