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Furanodiene induces G(2)/M cell cycle arrest and apoptosis through MAPK signaling and mitochondria-caspase pathway in human hepatocellular carcinoma cells
admin1,2; Yang, FQ1; Li, SP1; Gao, JL1; Hu, G1; Lao, SC1; Conceicao, EL1; Fung, KP3,4; Wang, YT1; Lee, SMY1,4
2007
Source PublicationCANCER BIOLOGY & THERAPY
Volume6Issue:7Pages:1044-1050
Abstract

Furanodiene (C15H20O), a pure compound isolated from Traditional Chinese medicine, Curcuma wenyujin, named Ezhu in Chinese, which structure was determined on the basis of NMR, MS and UV spectrum. In this study, we attempted to characterize in detail the signaling cascades resulted from furanodiene-induced apoptosis in human hepatoma HepG2 cells. Furanodiene inhibited HepG2 cell growth by causing cell cycle arrest at G(2)/M and inducing apoptosisas evidenced by DNA fragmentation assay. We found that furanodiene induced mitochondrial transmembrane depolarization, release of mitochondrial cytochrome c, activation of caspases-3 and the cleavage of PARP. The furanodiene mediated mitochondria-caspase apoptotic pathway also involved activation of p38 and inhibition of ERK mitogen-activated protein kinase (MAPK) signaling. These results for the first time have identified the biological activity of furanodiene against HepG2 cells and provide rationales for further development of essential oil of Ezhu and its ingredients such as furanodiene on treatment of liver diseases.

KeywordFuranodiene Apoptosis Hepg(2) Caspase-3 Mitochondrial Cytochrome c P38 Erk
DOIhttp://doi.org/10.4161/cbt.6.7.4317
URLView the original
Indexed BySCI
Language英语
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:000250805900020
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Cited Times [WOS]:44   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLee, SMY
Affiliation1.Institute of Chinese Medical Sciences; University of Macau; Taipa, Macao, P.R. China
2.State Drug Clinical Trial Agency; Science & Technology Department; Sichuan Provincial People’s Hospital; Sichuan Academy of Medical Science; Chengdu, P.R. China
3.Department of Biochemistry, The Chinese University of Hong Kong; Hong Kong, China
4.Institute of Chinese Medical; The Chinese University of Hong Kong; Hong Kong, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
admin,Yang, FQ,Li, SP,et al. Furanodiene induces G(2)/M cell cycle arrest and apoptosis through MAPK signaling and mitochondria-caspase pathway in human hepatocellular carcinoma cells[J]. CANCER BIOLOGY & THERAPY,2007,6(7):1044-1050.
APA admin.,Yang, FQ.,Li, SP.,Gao, JL.,Hu, G.,...&Lee, SMY.(2007).Furanodiene induces G(2)/M cell cycle arrest and apoptosis through MAPK signaling and mitochondria-caspase pathway in human hepatocellular carcinoma cells.CANCER BIOLOGY & THERAPY,6(7),1044-1050.
MLA admin,et al."Furanodiene induces G(2)/M cell cycle arrest and apoptosis through MAPK signaling and mitochondria-caspase pathway in human hepatocellular carcinoma cells".CANCER BIOLOGY & THERAPY 6.7(2007):1044-1050.
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