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NID1, a new regulator of EMT required for metastasis and chemoresistance of ovarian cancer cells
Zhou, Ya1,2; Zhu, Yuanyuan1,2; Fan, Xiaoyan1,2; Zhang, Chundong1,2; Wang, Yitao1,2; Zhang, Lian1,2; Zhang, Huan3; Wen, Tao4; Zhang, Kaina3; Huo, Xiao5; Jiang, Xue1,2; Bu, Youquan1,2; Zhang, Ying1,2
2017-05-16
Source PublicationONCOTARGET
ISSN1949-2553
Volume8Issue:20Pages:33110-33121
AbstractNidogen-1 (NID1) has been identified as a novel candidate diagnostic biomarker of ovarian cancer in our previous study. Nevertheless, the role of NID1 in the pathogenesis of ovarian cancer is unclear. In the present study, we demonstrated that NID1 was a mesenchymal associated gene and its high expression was significantly correlated with shorter overall survival of ovarian cancer patients. The ectopic expression of NID1 in OVCAR-3 cells revealed a epithelial-mesenchymal transition (EMT) phenotype accompanied by enhancement of motility, invasiveness and cisplatin resistance, whereas the knockdown of NID1 was sufficient to convert HEY cells into epithelial phenotype with decreased capability of motility, invasiveness and cisplatin resistance. Mechanistic studies disclosed that NID1 activated ERK/MAPK signaling pathway to promote EMT. Collectively, our findings have uncovered the molecular mechanisms of NID1 in promoting ovarian cancer metastasis and chemoresistance, and provide a rationale for the therapeutic potential of NID1 suppression in ovarian cancer.
Keywordovarian cancer NID1 EMT metastasis chemoresistance
DOI10.18632/oncotarget.16145
URLView the original
Indexed BySCI
Language英语
WOS Research AreaOncology ; Cell Biology
WOS SubjectOncology ; Cell Biology
WOS IDWOS:000401767700060
PublisherIMPACT JOURNALS LLC
The Source to ArticleWOS
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Cited Times [WOS]:17   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Chongqing Med Univ, Dept Biochem & Mol Biol, Chongqing 400016, Peoples R China;
2.Chongqing Med Univ, Mol Med & Canc Res Ctr, Chongqing 400016, Peoples R China;
3.Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China;
4.Chongqing Med Univ, Clin Coll 1, Chongqing 400016, Peoples R China;
5.Chongqing Med Univ, Coll Biomed Engn, Chongqing 400016, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Ya,Zhu, Yuanyuan,Fan, Xiaoyan,et al. NID1, a new regulator of EMT required for metastasis and chemoresistance of ovarian cancer cells[J]. ONCOTARGET,2017,8(20):33110-33121.
APA Zhou, Ya.,Zhu, Yuanyuan.,Fan, Xiaoyan.,Zhang, Chundong.,Wang, Yitao.,...&Zhang, Ying.(2017).NID1, a new regulator of EMT required for metastasis and chemoresistance of ovarian cancer cells.ONCOTARGET,8(20),33110-33121.
MLA Zhou, Ya,et al."NID1, a new regulator of EMT required for metastasis and chemoresistance of ovarian cancer cells".ONCOTARGET 8.20(2017):33110-33121.
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