UM
Interference of Quercetin on Astragalus Polysaccharide-Induced Macrophage Activation
Li, Zhi-Peng; Liu, Hong-Bing; Zhang, Quan-Wei; Li, Li-Feng; Bao, Wan-Rong; Ma, Dik-Lung; Leung, Chung-Hang; Bian, Zhao-Xiang; Lu, Ai-Ping; Han, Quan-Bin
2018-07
Source PublicationMOLECULES
ISSN1420-3049
Volume23Issue:7
AbstractPolysaccharides, which exert immunoregulatory effects, are becoming more and more popular as food supplements; however, certain components of ordinary foods could be reducing the polysaccharides beneficial effects. Quercetin, a flavonoid found in common fruits and vegetables, is one such component. This study investigated the effects of quercetin on Astragalus polysaccharide RAP induced-macrophage activation. The results show quercetin decreases the NO production and iNOS gene expression in RAW264.7 cells, and it inhibits the production of cytokines in RAW264.7 cells and peritoneal macrophages. Western blot analysis results suggest that quercetin inhibits the phosphorylation of Akt/mTORC1, MAPKs, and TBK1, but has no effect on NF-kappa B in RAP-induced RAW264.7 cells. Taken together, the results show that quercetin partly inhibits macrophage activation by the Astragalus polysaccharide RAP. This study demonstrates that quercetin-containing foods may interfere with the immune-enhancing effects of Astragalus polysaccharide RAP to a certain extent.
Keywordastragalus polysaccharide quercetin cytokines macrophage foods
DOI10.3390/molecules23071563
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000445301800066
PublisherMDPI
The Source to ArticleWOS
Fulltext Access
Citation statistics
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Li, Zhi-Peng,Liu, Hong-Bing,Zhang, Quan-Wei,et al. Interference of Quercetin on Astragalus Polysaccharide-Induced Macrophage Activation[J]. MOLECULES,2018,23(7).
APA Li, Zhi-Peng.,Liu, Hong-Bing.,Zhang, Quan-Wei.,Li, Li-Feng.,Bao, Wan-Rong.,...&Han, Quan-Bin.(2018).Interference of Quercetin on Astragalus Polysaccharide-Induced Macrophage Activation.MOLECULES,23(7).
MLA Li, Zhi-Peng,et al."Interference of Quercetin on Astragalus Polysaccharide-Induced Macrophage Activation".MOLECULES 23.7(2018).
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