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DJ-1 promotes colorectal cancer progression through activating PLAGL2/Wnt/BMP4 axis
Zhou, Jing1,2,3,4,5; Liu, Hao1,2; Zhang, Lian1,2; Liu, Xin1,2; Zhang, Chundong1,2; Wang, Yitao1,2; He, Qing1,2; Zhang, Ying1,2; Li, Yi1,2; Chen, Quanmei1,2; Zhang, Lu3,4,5; Wang, Kui3,4,5; Bu, Youquan1,2; Lei, Yunlong1,2
2018-08-29
Source PublicationCELL DEATH & DISEASE
ISSN2041-4889
Volume9
AbstractMetastasis remains a big barrier for the clinical treatment of colorectal cancer (CRC). Our previous proteomics analysis identified DJ-1 as a potential metastasis biomarker of CRC. In this study, we found that DJ-1 was upregulated in CRC. The levels of DJ-1 were closely correlated with the depths of invasion and predicted patient outcome. Enforced expression of DJ-1 could enhance CRC proliferation and metastasis in vitro and in vivo by stimulating Wnt-beta-catenin signaling. Specifically, DJ-1-induced beta-catenin nuclear translocation stimulated TCF transcription activity, which promoted BMP4 expression for CRC cell migration and invasion, and elevated CCND1 expression for CRC cell proliferation, respectively. Furthermore, DJ-1-induced Wnt signaling activation was dependent on PLAGL2 expression. In conclusion, our study demonstrates that DJ-1 can promote CRC metastasis by activating PLAGL2-Wnt-BMP4 axis, suggesting novel therapeutic opportunities for postoperative adjuvant therapy in CRC patients.
DOI10.1038/s41419-018-0883-4
URLView the original
Indexed BySCI
Language英语
WOS Research AreaCell Biology
WOS SubjectCell Biology
WOS IDWOS:000443088000001
PublisherNATURE PUBLISHING GROUP
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Chongqing Med Univ, Dept Biochem & Mol Biol, Chongqing 400016, Peoples R China;
2.Chongqing Med Univ, Mol Med & Canc Res Ctr, Chongqing 400016, Peoples R China;
3.Sichuan Univ, West China Sch Basic Med Sci & Forens Med, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China;
4.Sichuan Univ, West China Sch Basic Med Sci & Forens Med, West China Hosp, Canc Ctr, Chengdu 610041, Sichuan, Peoples R China;
5.Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Sichuan, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Jing,Liu, Hao,Zhang, Lian,et al. DJ-1 promotes colorectal cancer progression through activating PLAGL2/Wnt/BMP4 axis[J]. CELL DEATH & DISEASE,2018,9.
APA Zhou, Jing.,Liu, Hao.,Zhang, Lian.,Liu, Xin.,Zhang, Chundong.,...&Lei, Yunlong.(2018).DJ-1 promotes colorectal cancer progression through activating PLAGL2/Wnt/BMP4 axis.CELL DEATH & DISEASE,9.
MLA Zhou, Jing,et al."DJ-1 promotes colorectal cancer progression through activating PLAGL2/Wnt/BMP4 axis".CELL DEATH & DISEASE 9(2018).
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