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Anti-cancer drug research and development based on endoplasmic reticulum stress
Xu W.-S.; Lu J.-J.; Chen X.-P.; Wang Y.-T.
2012
Source PublicationChinese Pharmacological Bulletin
Volume28Issue:12Pages:1659
AbstractA number of physiologic or pathologic stimuli, such as hypoxia, calcium depletion or oxidative stress, may interrupt the function of endoplasmic reticulum and subsequently cause accumulation of unfolded or misfolded proteins which results in endoplasmic reticulum stress (ERS). ERS maintains cancer cell survival initially, but it may eventually trigger apoptosis etc. if endoplasmic reticulum dysfunction is severe or prolonged. Therefore, the drug research and development based on ERS might be a promising strategy for cancer therapy. Herein, the article introduces the progress of anti-cancer drug discovery based on ERS, summarizes some ERS inducers from natural products and analyzes the problems, as well as the prospect in this area.
KeywordCancer Drug research and development Endoplasmic reticulum stress Inducer Natural products Unfolded protein response
DOI10.3969/j.issn.1001-1978.2012.12.008
URLView the original
Language中文
The Source to ArticleScopus
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Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
AffiliationState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macao, 999078, Macau
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Xu W.-S.,Lu J.-J.,Chen X.-P.,et al. Anti-cancer drug research and development based on endoplasmic reticulum stress[J]. Chinese Pharmacological Bulletin,2012,28(12):1659.
APA Xu W.-S.,Lu J.-J.,Chen X.-P.,&Wang Y.-T..(2012).Anti-cancer drug research and development based on endoplasmic reticulum stress.Chinese Pharmacological Bulletin,28(12),1659.
MLA Xu W.-S.,et al."Anti-cancer drug research and development based on endoplasmic reticulum stress".Chinese Pharmacological Bulletin 28.12(2012):1659.
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