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γ-Mangostin, a xanthone from mangosteen, attenuates oxidative injury in liver via NRF2 and SIRT1 induction
Wang A.; Li D.; Wang S.; Zhou F.; Li P.; Wang Y.; Lin L.
2018
Source PublicationJournal of Functional Foods
ISSN1756-4646
Volume40Pages:544-553
Abstract

γ-Mangostin (γ-man), an active compound from Garcinia mangostana L., has been discovered as a hepatoprotective agent against oxidative injury. However, the underlying mechanisms remained unclear. The current study showed that γ-man stimulated the nuclear translocation of nuclear factor erythroid 2-related factor 2 (NRF2) to enhance antioxidant capacity under oxidative stress, which was partially reversed by treatment of the NRF2 inhibitor, all-trans-retinoic acid. Moreover, γ-man increased the expression and activity of SIRT1 (silent mating type information regulation 2 homolog 1), which facilitated the deacetylation of peroxisome proliferator-activated receptor γ coactivator 1α to improve the mitochondrial function in L02 cells. The protective effect of γ-man was partially blocked by treatment of the SIRT1 inhibitor tenovin-1 or SIRT1 knockdown. In vivo studies showed γ-man protected mice from carbon tetrachloride-induced acute liver injury, through up-regulation of NRF2 and SIRT1. Thus, γ-man might be a candidate to protect liver from acute oxidative injury. © 2017 Elsevier Ltd

KeywordΓ-mangostin Mangosteen Liver Oxidative Injury Nrf2 Sirt1 Pgc-1α
DOI10.1016/j.jff.2017.11.047
URLView the original
Indexed BySCI
Language英语
WOS Research AreaFood Science & Technology
WOS SubjectFood Science & Technology
WOS IDWOS:000428005500058
The Source to ArticleScopus
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorWang A.; Li D.; Wang S.; Zhou F.; Li P.; Wang Y.; Lin L.
AffiliationState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese, Medical Sciences, University of MacauMacao 999078, China
First Author AffilicationUniversity of Macau
Corresponding Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Wang A.,Li D.,Wang S.,et al. γ-Mangostin, a xanthone from mangosteen, attenuates oxidative injury in liver via NRF2 and SIRT1 induction[J]. Journal of Functional Foods,2018,40:544-553.
APA Wang A..,Li D..,Wang S..,Zhou F..,Li P..,...&Lin L..(2018).γ-Mangostin, a xanthone from mangosteen, attenuates oxidative injury in liver via NRF2 and SIRT1 induction.Journal of Functional Foods,40,544-553.
MLA Wang A.,et al."γ-Mangostin, a xanthone from mangosteen, attenuates oxidative injury in liver via NRF2 and SIRT1 induction".Journal of Functional Foods 40(2018):544-553.
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