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Synthesis and characterization of an amphiphilic linoleic acid-g-quaternary chitosan with low toxicity
Fang X.; Xu Y.; Zhang J.; Lu X.; Wang Y.; Chen M.
2015
Source PublicationJournal of Nanomaterials
Volume2015
Abstract

A novel amphiphilic derivative of chitosan, namely, a linoleic acid-g-quaternary chitosan (LA-g-QC), was designed and synthesized as low toxic material for biomedical applications in this study. The chemical structure of LA-g-QC was characterized by Fourier transform infrared spectroscopy (FTIR), 1H nuclear magnetic resonance (1H-NMR), and elemental analysis. LA-g-QC could form nanosized micelles with self-assembly, which was confirmed by the results of critical micelle concentration (CMC) via fluorescence spectroscopy. The average size of LA-g-QC was 140 nm and its zeta potential was approximately +35.50 mV. CMC value was 31.00 mg/mL. Furthermore, LA-g-QC micelles, at final concentrations between 0.94 μg/mL and 30 μg/mL, did not inhibit the proliferation of HepG2 or SMMC 7721 cell lines. Taken together, LA-g-QC has low cytotoxicity and high potential for the preparation of novel drug-delivery micelles. © 2015 Xiaobin Fang et al.

DOI10.1155/2015/568925
URLView the original
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000361239900001
The Source to ArticleScopus
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau
2.Translation Medicine Research Center, Lishui People's Hospital, Sixth Affiliated Hospital, Wenzhou Medical University, Lishui, Zhejiang, 323000, China
Recommended Citation
GB/T 7714
Fang X.,Xu Y.,Zhang J.,et al. Synthesis and characterization of an amphiphilic linoleic acid-g-quaternary chitosan with low toxicity[J]. Journal of Nanomaterials,2015,2015.
APA Fang X.,Xu Y.,Zhang J.,Lu X.,Wang Y.,&Chen M..(2015).Synthesis and characterization of an amphiphilic linoleic acid-g-quaternary chitosan with low toxicity.Journal of Nanomaterials,2015.
MLA Fang X.,et al."Synthesis and characterization of an amphiphilic linoleic acid-g-quaternary chitosan with low toxicity".Journal of Nanomaterials 2015(2015).
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