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A comparative investigation between paclitaxel nanoparticle- and nanocrystal-loaded thermosensitive PECT hydrogels for peri-tumoural administration
Lin Z.1,2; Xu S.2; Gao W.2; Hu H.2; Chen M.4; Wang Y.4; He B.2; Dai W.2; Zhang H.2; Wang X.2; Dong A.3; Yin Y.1; Zhang Q.2
2016
Source PublicationNanoscale
Volume8Issue:44Pages:18782
Abstract

For in situ thermosensitive hydrogels, it is a big challenge to achieve high drug loading, long-term local retention, and effective drug release simultaneously. To address these issues, we combined the strategy of drug nanocrystals (NCs) and thermosensitive hydrogels with higher gel strength. In particular, we developed paclitaxel NC-based hydrogels using PECT, a thermosensitive polymer synthesized by us (PTX-NC-PECT), and a nanoparticle-based system was used as the control (PTX-NP-PECT). First, high levels of PTX could be loaded in both PECT hydrogels. Moreover, in vivo near infrared fluorescence (NIRF) imaging showed that both hydrogel systems were able to maintain the payloads of 1,1-dioctadecyltetramethyl indotricarbocyanine iodide (DiR) at a peri-tumoural site for at least 21 days, much longer than that achieved with the control hydrogel of Pluronic® F127. Furthermore, we observed that PTX-NCs released free PTX more effectively and homogeneously than PTX-NPs in vitro. It was further verified in vivo that the release of DiR from DiR-NC-PECT was more complete than that from DiR-NP-PECT. Finally, PTX-NC-PECT gel demonstrated the strongest anti-tumour efficacy on MCF-7 breast cancer. In conclusion, PTX-NC-PECT hydrogel might be a high-performance thermosensitive hydrogel for local cancer therapy. © 2016 The Royal Society of Chemistry.

KeywordDrug-delivery Systems Breast-cancer Sustained Delivery Ovarian-cancer Release Therapy Copolymers Efficacy Microparticles Formulation
DOIhttp://doi.org/10.1039/c6nr05498f
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS IDWOS:000387858700025
The Source to ArticleScopus
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Cited Times [WOS]:6   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorDong A.; Yin Y.; Zhang Q.
Affiliation1.Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University, Beijing, 100191, China
2.Beijing Key Laboratory of Molecular Pharmaceutics, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China
3.School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China
4.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau999078, Macau
Recommended Citation
GB/T 7714
Lin Z.,Xu S.,Gao W.,et al. A comparative investigation between paclitaxel nanoparticle- and nanocrystal-loaded thermosensitive PECT hydrogels for peri-tumoural administration[J]. Nanoscale,2016,8(44):18782.
APA Lin Z..,Xu S..,Gao W..,Hu H..,Chen M..,...&Zhang Q..(2016).A comparative investigation between paclitaxel nanoparticle- and nanocrystal-loaded thermosensitive PECT hydrogels for peri-tumoural administration.Nanoscale,8(44),18782.
MLA Lin Z.,et al."A comparative investigation between paclitaxel nanoparticle- and nanocrystal-loaded thermosensitive PECT hydrogels for peri-tumoural administration".Nanoscale 8.44(2016):18782.
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