UM
Self-stabilized silk sericin-based nanoparticles: In vivo biocompatibility and reduced doxorubicin-induced toxicity
Hu, Doudou; Li, Ting; Xu, Zongpu; Liu, Di; Yang, Mingying; Zhu, Liangjun
2018-07
Source PublicationACTA BIOMATERIALIA
ISSN1742-7061
Volume74Pages:385-396
AbstractA variety of colloid stabilizers and cryoprotectants confer improved nanoparticle (NP) colloidal stability and redisperability. However, discounted tumor targetability, delivery efficacy and possible side effects limit the application in vascular delivery of NPs. Here we present water-soluble silk sericin (SS) not only as a material for the preparation of NPs, but also both a dispersion stabilizer and a cryoprotectant. In the absence of any stabilizers, SS-based NPs (SSC@NPs) can resist the adsorption of serum proteins, preventing the formation of particle agglomerates. Following freeze-drying without addition of cryoprotectants, SSC@NPs powder can be easily resuspended into NP dispersion with a nearly monodispersed distribution. Additionally, SSC@NPs do not result in acute toxicity in mice at a dose of 400 mg/kg with a slow injection. Moreover, doxorubicin (DOX)-loaded SSC@NPs (DOX-SSC@NPs) diminish the biodistribution of DOX in the heart, mitigating DOX-induced cardiotoxicity of mice without compromising therapeutic efficacy. Our results suggest that the self-stabilized SSC@NPs could be a secure and effective drug carrier for intravenous administration when deprived of protective agents.
KeywordColloidal stability Hydrophilicity Water-soluble silk sericin Freeze-drying Dispersion stabilizer Cryoprotectant Doxorubicin
DOI10.1016/j.actbio.2018.05.024
URLView the original
Indexed BySCI
Language英语
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, Biomaterials
WOS IDWOS:000437998200030
PublisherELSEVIER SCI LTD
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Hu, Doudou,Li, Ting,Xu, Zongpu,et al. Self-stabilized silk sericin-based nanoparticles: In vivo biocompatibility and reduced doxorubicin-induced toxicity[J]. ACTA BIOMATERIALIA,2018,74:385-396.
APA Hu, Doudou,Li, Ting,Xu, Zongpu,Liu, Di,Yang, Mingying,&Zhu, Liangjun.(2018).Self-stabilized silk sericin-based nanoparticles: In vivo biocompatibility and reduced doxorubicin-induced toxicity.ACTA BIOMATERIALIA,74,385-396.
MLA Hu, Doudou,et al."Self-stabilized silk sericin-based nanoparticles: In vivo biocompatibility and reduced doxorubicin-induced toxicity".ACTA BIOMATERIALIA 74(2018):385-396.
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