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Berberine Regulated Lipid Metabolism in the Presence of C75, Compound C, and TOFA in Breast Cancer Cell Line MCF-7
Tan W.; Zhong Z.; Wang S.; Suo Z.; Yang X.; Hu X.; Wang Y.
2015
Source PublicationEvidence-based Complementary and Alternative Medicine
Volume2015
Abstract

Berberine interfering with cancer reprogramming metabolism was confirmed in our previous study. Lipid metabolism and mitochondrial function were also the core parts in reprogramming metabolism. In the presence of some energy-related inhibitors, including C75, compound C, and TOFA, the discrete roles of berberine in lipid metabolism and mitochondrial function were elucidated. An altered lipid metabolism induced by berberine was observed under the inhibition of FASN, AMPK, and ACC in breast cancer cell MCF-7. And the reversion of berberine-induced lipid suppression indicated that ACC inhibition might be involved in that process instead of FASN inhibition. A robust apoptosis induced by berberine even under the inhibition of AMPK and lipid synthesis was also indicated. Finally, mitochondrial function regulation under the inhibition of AMPK and ACC might be in an ACL-independent manner. Undoubtedly, the detailed mechanisms of berberine interfering with lipid metabolism and mitochondrial function combined with energy-related inhibitors need further investigation, including the potential compensatory mechanisms for ATP production and the upregulation of ACL. © 2015 Wen Tan et al.

DOI10.1155/2015/396035
URLView the original
Indexed BySCI
Language英语
WOS Research AreaIntegrative & Complementary Medicine
WOS SubjectIntegrative & Complementary Medicine
WOS IDWOS:000360131100001
The Source to ArticleScopus
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Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.School of Pharmacy, Lanzhou University, 199 West Donggang Road, Lanzhou, Gansu, 730000, China
2.Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macau, Brazil
Recommended Citation
GB/T 7714
Tan W.,Zhong Z.,Wang S.,et al. Berberine Regulated Lipid Metabolism in the Presence of C75, Compound C, and TOFA in Breast Cancer Cell Line MCF-7[J]. Evidence-based Complementary and Alternative Medicine,2015,2015.
APA Tan W..,Zhong Z..,Wang S..,Suo Z..,Yang X..,...&Wang Y..(2015).Berberine Regulated Lipid Metabolism in the Presence of C75, Compound C, and TOFA in Breast Cancer Cell Line MCF-7.Evidence-based Complementary and Alternative Medicine,2015.
MLA Tan W.,et al."Berberine Regulated Lipid Metabolism in the Presence of C75, Compound C, and TOFA in Breast Cancer Cell Line MCF-7".Evidence-based Complementary and Alternative Medicine 2015(2015).
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