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Bisdemethoxycurcumin increases Sirt1 to antagonize t -BHP-induced premature senescence in WI38 fibroblast cells
Li Y.-B.1,2; Zhong Z.-F.1; Chen M.-W.1; Bao J.-L.1; Wu G.-S.1; Zhang Q.-W.1; Lee S.M.-Y.1; Hoi P.-M.1; Wang Y.-T.1
2013
Source PublicationEvidence-based Complementary and Alternative Medicine
Volume2013
Abstract

Curcuminoids are well known for their capabilities to combat risk factors that are associated with ageing and cellular senescence. Recent reports have demonstrated that curcuminoids can extend the lifespan of model organisms. However, the underlying mechanisms by which these polyphenic compounds exert these beneficial effects remain unknown. In this study, t-BHP-induced premature senescence model in human fibroblasts was chosen to explore the protective effects of a curcuminoid, bisdemethoxycurcumin (BDMC), on cellular senescence. The results demonstrated that BDMC attenuated oxidative stress-induced senescence-like features which include the induction of an enlarged cellular appearance, higher frequency of senescence-associated β-galactosidase staining activity, appearance of senescence-associated heterochromatic foci in nuclei, decrease in proliferation capability, and alteration in related molecules such as p16 and retinoblastoma protein. Notably, we found that BDMC treatment activated Sirt1/AMPK signaling pathway. Moreover, downregulating Sirt1 by the pharmacological inhibitor nicotianamine or small interfering RNA blocked BDMC-mediated protection against t-BHP-mediated decrease in proliferation. These results suggested that BDMC prevented t-BHP-induced cellular senescence, and BDMC-induced Sirt1 may be a mechanism mediating its beneficial effects. © 2013 Ying-Bo Li et al.

DOI10.1155/2013/851714
URLView the original
Language英语
The Source to ArticleScopus
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被引频次[WOS]:5   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题Institute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenue Padre Tomás Pereira S.J., Taipa 999078, Macau
2.State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
First Author AffilicationInstitute of Chinese Medical Sciences
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Li Y.-B.,Zhong Z.-F.,Chen M.-W.,et al. Bisdemethoxycurcumin increases Sirt1 to antagonize t -BHP-induced premature senescence in WI38 fibroblast cells[J]. Evidence-based Complementary and Alternative Medicine,2013,2013.
APA Li Y.-B..,Zhong Z.-F..,Chen M.-W..,Bao J.-L..,Wu G.-S..,...&Wang Y.-T..(2013).Bisdemethoxycurcumin increases Sirt1 to antagonize t -BHP-induced premature senescence in WI38 fibroblast cells.Evidence-based Complementary and Alternative Medicine,2013.
MLA Li Y.-B.,et al."Bisdemethoxycurcumin increases Sirt1 to antagonize t -BHP-induced premature senescence in WI38 fibroblast cells".Evidence-based Complementary and Alternative Medicine 2013(2013).
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