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Berberine interfered with breast cancer cells metabolism, balancing energy homeostasis
Tan W.; Li N.; Tan R.; Zhong Z.; Suo Z.; Yang X.; Wang Y.; Hu X.
Source PublicationAnti-Cancer Agents in Medicinal Chemistry

Berberine exerted anti-cancer effect in various cancer cell lines, and was also implied in the treatment of metabolic related diseases. Given the metabolic modulation, we hypothesized that berberine possessed anti-cancer effect under the assistance of metabolic interference. Working as a modulator, metabolic enzyme inhibitor or complex network regulator in energy metabolism, berberine was highlighted in current cancer research. A reasonable cross talk between Chinese medicine and energy homeostasis provided a solid foundation for berberine interference on cancer cells reprogramming metabolism. Our result showed that berberine regulated the reprogramming metabolism through three aspects simultaneously, including mitochondrial oxidative phosphorylation, glycolysis and macromolecular synthesis. This interference with reprogramming metabolism was a continuous, simultaneous and sustainable approach in a moderate mode. And it could be regarded as a gentle and virtuous cycle from a multi-level perspective, indicating an integrated approach in cancer therapy. Meanwhile, we thought that Chinese medicine could link cancer and metabolic related diseases from a dynamic perspective through integrated network pharmacology. This cross talk would be a realistic and significant strategy for anti-cancer drug discovery and needs further investigation in future. © 2015 Bentham Science Publishers

KeywordBerberine Chinese Medicine Energy Homeostasis Mcf-7 Reprogramming Metabolism
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Indexed BySCI
WOS Research AreaOncology ; Pharmacology & Pharmacy
WOS SubjectOncology ; Chemistry, Medicinal
WOS IDWOS:000351210300012
The Source to ArticleScopus
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Cited Times [WOS]:6   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.School of Pharmacy, Lanzhou University, Lanzhou, Gansu province, China
2.Institute of Chinese Medical Sciences, University of Macau, Macao Special Administrative Region, China
3.State Key Laboratory of Quality Research in Chinese Medicine, Macao Special Administrative Region, China
4.School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan province, China
Recommended Citation
GB/T 7714
Tan W.,Li N.,Tan R.,et al. Berberine interfered with breast cancer cells metabolism, balancing energy homeostasis[J]. Anti-Cancer Agents in Medicinal Chemistry,2015,15(1):66.
APA Tan W..,Li N..,Tan R..,Zhong Z..,Suo Z..,...&Hu X..(2015).Berberine interfered with breast cancer cells metabolism, balancing energy homeostasis.Anti-Cancer Agents in Medicinal Chemistry,15(1),66.
MLA Tan W.,et al."Berberine interfered with breast cancer cells metabolism, balancing energy homeostasis".Anti-Cancer Agents in Medicinal Chemistry 15.1(2015):66.
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