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Inhibition of TLR1/2 dimerization by enantiomers of metal complexes
Liu L.-J.1; Wang W.2; Zhong Z.1; Lin S.2; Lu L.1; Wang Y.-T.1; Ma D.-L.2; Leung C.-H.1
2016
Source PublicationChemical Communications
Volume52Issue:83Pages:12278
Abstract

We report herein the identification of an immunomodulatory metal-based complex 1 as a direct inhibitor of TLR1/2 heterodimerization. Both enantiomers of complex 1 selectively suppressed TNF-α and TLR1/2 heterodimerization in Pam3CSK4-induced macrophages, with Λ-1 being more potent than Δ-1. Moreover, the complexes inhibited NF-κB transduction via the modulation of TLR1/2 signaling. To our knowledge, complex 1 is the first metal-based inhibitor of TLR1/2 heterodimerization reported to date. © 2016 The Royal Society of Chemistry.

DOI10.1039/c6cc06155a
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000385166800002
The Source to ArticleScopus
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Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorMa D.-L.; Leung C.-H.
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau
2.Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Liu L.-J.,Wang W.,Zhong Z.,et al. Inhibition of TLR1/2 dimerization by enantiomers of metal complexes[J]. Chemical Communications,2016,52(83):12278.
APA Liu L.-J..,Wang W..,Zhong Z..,Lin S..,Lu L..,...&Leung C.-H..(2016).Inhibition of TLR1/2 dimerization by enantiomers of metal complexes.Chemical Communications,52(83),12278.
MLA Liu L.-J.,et al."Inhibition of TLR1/2 dimerization by enantiomers of metal complexes".Chemical Communications 52.83(2016):12278.
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