UM  > 中華醫藥研究院
Discrimination of Three Panax Species Based on Differences in Volatile Organic Compounds Using a Static Headspace GC-MS-Based Metabolomics Approach
Chen X.-J.; Qiu J.-F.; Wang Y.-T.; Wan J.-B.
2016
Source PublicationAmerican Journal of Chinese Medicine
Volume44Issue:3Pages:663
Abstract

Panax ginseng (Asian ginseng), Panax quinquefolium (American ginseng) and Panax notoginseng (notoginseng) are highly valuable tonic herbs derived from the Panax genus that have similar morphological appearances and odors but different pharmacological activities and clinical indications. Thus, the authentication of these three Panax species is crucial for ensuring the quality, safety and efficacy of medication. In the present study, a static headspace gas chromatography - mass spectrometry (GC-MS) followed by a multivariate statistical analysis was developed to globally characterize the volatile organic compound (VOC) profiles in P. ginseng, P. quinquefolium, and P. notoginseng, and subsequently to discover differentiating chemical markers. Under the optimized conditions, the headspace VOCs of a total of 49 batches of Panax herbs derived from the three Panax species were profiled, and the dataset of sample code, tR-m/z pair and ion intensity was processed by unsupervised principal component analysis (PCA) and by supervised partial least squared discriminant analysis (PLS-DA) to comprehensively compare the chemical differences in Panax across the species. The results demonstrated that Panax herbs derived from three species possess obviously diverse chemical characteristics of VOCs, PCA, and PLS-DA. According to their VOC profiles, 49 tested samples could be clearly differentiated according to species. Chemomarker 1, 2, and 4 might be used as unique chemical markers of P. ginseng, P. notoginseng and P. quinquefolium, respectively. Our findings indicate that static headspace GC-MS-based VOC profiling, combined with multivariate statistical analysis, provide a reliable tool to discriminate between the three Panax species and to identify their differentiation markers, which will be helpful for ensuring their quality, safety and efficacy. © 2016 World Scientific Publishing Company.

KeywordMetabolomics Multivariate Statistical Analysis Panax Species Static Headspace Gc-ms Volatile Organic Compounds
DOIhttp://doi.org/10.1142/S0192415X16500361
URLView the original
Indexed BySCI
Language英语
WOS Research AreaIntegrative & Complementary Medicine ; General & Internal Medicine
WOS SubjectIntegrative & Complementary Medicine ; Medicine, General & Internal
WOS IDWOS:000377676300012
The Source to ArticleScopus
Fulltext Access
Citation statistics
Cited Times [WOS]:9   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorWang Y.-T.; Wan J.-B.
AffiliationState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, C-Macao, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Chen X.-J.,Qiu J.-F.,Wang Y.-T.,et al. Discrimination of Three Panax Species Based on Differences in Volatile Organic Compounds Using a Static Headspace GC-MS-Based Metabolomics Approach[J]. American Journal of Chinese Medicine,2016,44(3):663.
APA Chen X.-J.,Qiu J.-F.,Wang Y.-T.,&Wan J.-B..(2016).Discrimination of Three Panax Species Based on Differences in Volatile Organic Compounds Using a Static Headspace GC-MS-Based Metabolomics Approach.American Journal of Chinese Medicine,44(3),663.
MLA Chen X.-J.,et al."Discrimination of Three Panax Species Based on Differences in Volatile Organic Compounds Using a Static Headspace GC-MS-Based Metabolomics Approach".American Journal of Chinese Medicine 44.3(2016):663.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Chen X.-J.]'s Articles
[Qiu J.-F.]'s Articles
[Wang Y.-T.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Chen X.-J.]'s Articles
[Qiu J.-F.]'s Articles
[Wang Y.-T.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Chen X.-J.]'s Articles
[Qiu J.-F.]'s Articles
[Wang Y.-T.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.