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Furanodiene enhances the anti-cancer effects of doxorubicin on ERα-negative breast cancer cells in vitro
Zhong Z.-F.; Qiang W.-A.; Wang C.-M.; Tan W.; Wang Y.-T.
2016
Source PublicationEuropean Journal of Pharmacology
Volume774Pages:10
Abstract

Furanodiene is a natural product isolated from Rhizoma curcumae, and exhibits broad-spectrum anti-cancer activities in vitro and in vivo. Our previous study proved that furanodiene could increase growth inhibition of steroidal agent in ERα-positive breast cancer cells, but whether furanodiene can influence ER status is not clear. In this study, we confirmed that furanodiene down-regulated the ERα protein expression level and inhibited E2-induced estrogen response element (ERE)-driven reporter plasmid activity in ERα-positive MCF-7 cells. Actually, ERα-knockdown cells were more sensitive than ERα positive cells to furanodiene on the cytotoxicity effect. So the anti-cancer effects of furanodiene and non-steroidal agent in breast cancer cells still requires further investigation. Our results showed that furanodiene exposure could enhance growth inhibitory effects of doxorubicin in ERα-negative MDA-MB-231 cells and ERα-low expression 4T1 cells. However, furanodiene did not increase the cytotoxicity of doxorubicin in ERα-positive breast cancer cells, non-tumorigenic breast epithelial cells, macrophage cells, hepatocytes cells, pheochromocytoma cells and cardiac myoblasts cells. Furanodiene enhances the anti-cancer effects of doxorubicin in ERα-negative breast cancer cells through suppressing cell viability via inducing apoptosis in mitochondria-caspases-dependent and reactive oxygen species-independent manners. These results indicate that furanodiene may be a promising and safety natural agent for cancer adjuvant therapy in the future. © 2016 Published by Elsevier B.V.

KeywordApoptosis Breast Cancer Combination Doxorubicin Furanodiene
DOI10.1016/j.ejphar.2015.11.039
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000370824100002
The Source to ArticleScopus
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Cited Times [WOS]:10   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macau, China
2.Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States
3.School of Pharmacy, Lanzhou University, 199 West Dong-gang Rd., Lanzhou, Gansu, China
Recommended Citation
GB/T 7714
Zhong Z.-F.,Qiang W.-A.,Wang C.-M.,et al. Furanodiene enhances the anti-cancer effects of doxorubicin on ERα-negative breast cancer cells in vitro[J]. European Journal of Pharmacology,2016,774:10.
APA Zhong Z.-F.,Qiang W.-A.,Wang C.-M.,Tan W.,&Wang Y.-T..(2016).Furanodiene enhances the anti-cancer effects of doxorubicin on ERα-negative breast cancer cells in vitro.European Journal of Pharmacology,774,10.
MLA Zhong Z.-F.,et al."Furanodiene enhances the anti-cancer effects of doxorubicin on ERα-negative breast cancer cells in vitro".European Journal of Pharmacology 774(2016):10.
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