UM  > 中華醫藥研究院
A Naturally Derived, Growth Factor-Binding Polysaccharide for Therapeutic Angiogenesis
Li Q.1; Guo G.2; Meng F.1; Wang H.H.1; Niu Y.1; Zhang Q.1; Zhang J.2; Wang Y.1; Dong L.2; Wang C.1
2016
Source PublicationACS Macro Letters
Volume5Issue:5Pages:617
Abstract

We herein report the discovery of a naturally derived carbohydrate with binding affinities for two pro-angiogenic growth factors-fibroblast growth factor-2 (FGF-2) and platelet-derived growth factor-BB (PDGF-BB). This galacturonic acid-containing polysaccharide (EUP3) sequestered endogenous FGF-2 and PDGF-BB in vivo and promoted in situ formation and maturation of new blood vessels. Our findings suggest EUP3 as the first nonglycosaminoglycan, nonanimal-originated carbohydrate molecule that binds two pro-angiogenic growth factors to stimulate angiogenesis. Further investigations into this carbohydrate may lead to the development of new tools for therapeutic angiogenesis. © 2016 American Chemical Society.

DOIhttp://doi.org/10.1021/acsmacrolett.6b00182
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPolymer Science
WOS SubjectPolymer Science
WOS IDWOS:000376225800014
The Source to ArticleScopus
Fulltext Access
Citation statistics
Cited Times [WOS]:13   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau
2.State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210093, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Li Q.,Guo G.,Meng F.,et al. A Naturally Derived, Growth Factor-Binding Polysaccharide for Therapeutic Angiogenesis[J]. ACS Macro Letters,2016,5(5):617.
APA Li Q..,Guo G..,Meng F..,Wang H.H..,Niu Y..,...&Wang C..(2016).A Naturally Derived, Growth Factor-Binding Polysaccharide for Therapeutic Angiogenesis.ACS Macro Letters,5(5),617.
MLA Li Q.,et al."A Naturally Derived, Growth Factor-Binding Polysaccharide for Therapeutic Angiogenesis".ACS Macro Letters 5.5(2016):617.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li Q.]'s Articles
[Guo G.]'s Articles
[Meng F.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li Q.]'s Articles
[Guo G.]'s Articles
[Meng F.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li Q.]'s Articles
[Guo G.]'s Articles
[Meng F.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.