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Nanoparticle-mediated inhibition of survivin to overcome drug resistance in cancer therapy
Wang S.1; Xu Y.1; Chan H.F.2; Kim H.-W.3; Wang Y.1; Leong K.W.2; Chen M.1
2016
Source PublicationJournal of Controlled Release
Volume240Pages:454
Abstract

The acquired resistance of human cancer cells to apoptosis is one of the defining hallmarks of cancer. Upregulated expression of inhibitors of apoptosis proteins (IAP) has been implicated in drug resistance in several cancers. Survivin (encoded by BIRC5), the smallest member of the IAP family, has been correlated with both the control of cell apoptosis and regulation of cell mitosis in cancer. Owing to its critical role in regulation of cell survival and development of cancer resistance, as well as its distinguishingly high level of expression in many types of cancer, survivin has long been regarded as a promising therapeutic target for cancer therapy. This review first presents an overview of the mechanism by which survivin regulates cell function, followed by a discussion of the current state of survivin-targeted therapies. We focus on the application of nanoparticulate systems to deliver survivin inhibitors, co-delivery of survivin inhibitors with chemotherapeutic agents, synchronous targeting of survivin, other drug resistant molecules, and survivin regulators. We conclude by highlighting the current limitations associated with survivin-targeted therapies and speculating on the future strategies to surmount these impediments. © 2016 Elsevier B.V.

KeywordApoptosis Cancer Drug Resistance Nanoparticles Survivin
DOIhttp://doi.org/10.1016/j.jconrel.2016.04.018
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS SubjectChemistry, Multidisciplinary ; Pharmacology & Pharmacy
WOS IDWOS:000386250700036
The Source to ArticleScopus
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Cited Times [WOS]:19   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLeong K.W.; Chen M.
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of MacauMacau, China
2.Department of Biomedical Engineering, Columbia University, New York, NY 10027, United States
3.Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, 330-714, South Korea
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Wang S.,Xu Y.,Chan H.F.,et al. Nanoparticle-mediated inhibition of survivin to overcome drug resistance in cancer therapy[J]. Journal of Controlled Release,2016,240:454.
APA Wang S..,Xu Y..,Chan H.F..,Kim H.-W..,Wang Y..,...&Chen M..(2016).Nanoparticle-mediated inhibition of survivin to overcome drug resistance in cancer therapy.Journal of Controlled Release,240,454.
MLA Wang S.,et al."Nanoparticle-mediated inhibition of survivin to overcome drug resistance in cancer therapy".Journal of Controlled Release 240(2016):454.
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