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Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense
Zhu Y.; Xu J.; Sun C.; Zhou S.; Xu H.; Nelson D.R.; Qian J.; Song J.; Luo H.; Xiang L.; Li Y.; Xu Z.; Ji A.; Wang L.; Lu S.; Hayward A.; Sun W.; Li X.; Schwartz D.C.; Wang Y.; Chen S.
2015
Source PublicationScientific Reports
Volume5
Abstract

Fungi have evolved powerful genomic and chemical defense systems to protect themselves against genetic destabilization and other organisms. However, the precise molecular basis involved in fungal defense remain largely unknown in Basidiomycetes. Here the complete genome sequence, as well as DNA methylation patterns and small RNA transcriptomes, was analyzed to provide a holistic overview of secondary metabolism and defense processes in the model medicinal fungus, Ganoderma sinense. We reported the 48.96 Mb genome sequence of G. sinense, consisting of 12 chromosomes and encoding 15,688 genes. More than thirty gene clusters involved in the biosynthesis of secondary metabolites, as well as a large array of genes responsible for their transport and regulation were highlighted. In addition, components of genome defense mechanisms, namely repeat-induced point mutation (RIP), DNA methylation and small RNA-mediated gene silencing, were revealed in G. sinense. Systematic bioinformatic investigation of the genome and methylome suggested that RIP and DNA methylation combinatorially maintain G. sinense genome stability by inactivating invasive genetic material and transposable elements. The elucidation of the G. sinense genome and epigenome provides an unparalleled opportunity to advance our understanding of secondary metabolism and fungal defense mechanisms.

DOI10.1038/srep11087
URLView the original
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000355879400001
The Source to ArticleScopus
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Cited Times [WOS]:16   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China
2.Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China
3.Laboratory for Molecular and Computational Genomics, Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, United States
4.Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN 38163, United States
5.Queensland Alliance for Agriculture and Food Innovation, University of Queensland, Brisbane, 4072, Australia
6.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau999078, Macau
Recommended Citation
GB/T 7714
Zhu Y.,Xu J.,Sun C.,et al. Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense[J]. Scientific Reports,2015,5.
APA Zhu Y..,Xu J..,Sun C..,Zhou S..,Xu H..,...&Chen S..(2015).Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.Scientific Reports,5.
MLA Zhu Y.,et al."Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense".Scientific Reports 5(2015).
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